Evidence map›Paper›PMID 35357221›Full record

ArticleInfection and immunity2022

Methamphetamine Enhances Cryptococcus neoformans Melanization, Antifungal Resistance, and Pathogenesis in a Murine Model of Drug Administration and Systemic Infection.

Victor H Erives, Melissa E Munzen, Daniel Zamith-Miranda, Hazael Hernandez, Swetha Manepalli, Long N Nguyen, Mohamed F Hamed, Joshua D Nosanchuk, Luis R Martinez

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Fungal Infections in People Who Use Drugs.Open forum infectious diseases · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Victor H ErivesDepartment of Biological Sciences, The Border Biomedical Research Center, The University of Texas at El Pasogrid.267324.6, El Paso, Texas, USA.
Melissa E MunzenDepartment of Oral Biology, University of Floridagrid.15276.37 College of Dentistry, Gainesville, Florida, USA.
Daniel Zamith-MirandaDepartment of Medicine (Division of Infectious Diseases), Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0001-7532-2432
Hazael HernandezDepartment of Biological Sciences, The Border Biomedical Research Center, The University of Texas at El Pasogrid.267324.6, El Paso, Texas, USA.
Swetha ManepalliDepartment of Biomedical Sciences, Long Island University-Post, Brookville, New York, USA.
Long N NguyenDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Mohamed F HamedDepartment of Oral Biology, University of Floridagrid.15276.37 College of Dentistry, Gainesville, Florida, USA.
Joshua D NosanchukDepartment of Medicine (Division of Infectious Diseases), Albert Einstein College of Medicine, Bronx, New York, USA.
Luis R MartinezDepartment of Oral Biology, University of Floridagrid.15276.37 College of Dentistry, Gainesville, Florida, USA.ORCID 0000-0001-6372-6501
Albert Einstein College of Medicine · USLong Island University · USMansoura University · EGNational University of Singapore · SGTexas Tech University · USThe University of Texas at El Paso · USUniversity of Florida · US

Funding

Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
Unraveling Cryptococcus neoformans mechanisms of brain invasion and colonizationR01AI145559 · NIAID · UNIVERSITY OF TEXAS EL PASO · PI MARTINEZ, LUIS R · 2019 to 2023
$2.6M
NIAID NIH HHS R01 AI052733NIAID NIH HHS R01 AI145559
6 · The paper itself

Abstract

Methamphetamine (METH) is a major public health and safety problem in the United States. Chronic METH abuse is associated with a 2-fold-higher risk of HIV infection and, possibly, additional infections, particularly those that enter through the respiratory tract or skin. Cryptococcus neoformans is an encapsulated opportunistic yeast-like fungus that is a relatively frequent cause of meningoencephalitis in immunocompromised patients, especially in individuals with AIDS. C. neoformans melanizes during mammalian infection in a process that presumably uses host-supplied compounds such as catecholamines. l-3,4-Dihydroxyphenylalanine (l-Dopa) is a natural catecholamine that is frequently used to induce melanization in C. neoformans. l-Dopa-melanized cryptococci manifest resistance to radiation, phagocytosis, detergents, and heavy metals. Using a systemic mouse model of infection and

Indexed as

CryptococcosisCryptococcus neoformansHIV InfectionsMethamphetamineSepsisAnimalsAntifungal AgentsDisease Models, AnimalHumansLevodopaMammalsMelaninsMiceSaccharomyces cerevisiaeAntifungal AgentsLevodopaMelaninsMethamphetamineantifungal drugsC. neoformansinfectionmelaninmethamphetaminevirulence

Identifiers

PMID35357221
PMCPMC9022586
OpenAlexW4221057480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.