Evidence map›Paper›PMID 35357020›Full record

SynthesisArtificial organs2022

Technology landscape of pediatric mechanical circulatory support devices: A systematic review 2010-2021.

Thomas Palazzolo, Matthew Hirschhorn, Ellen Garven, Steven Day, Randy M Stevens, Joseph Rossano, Vakhtang Tchantchaleishvili, Amy L Throckmorton

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Artificial organs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Series Multiblood Pump Design With Dual Activation for Pediatric Patients With Heart Failure.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2025
    Article
  4. Review
  5. Article
  6. Next Generation Development of Hybrid Continuous Flow Pediatric Total Artificial Heart Technology: Design-Build-Test.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thomas PalazzoloBioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA.
Matthew HirschhornBioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-4986-4021
Ellen GarvenBioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-3773-8928
Steven DayDepartment of Biomedical Engineering, Kate Gleason College of Engineering, Rochester Institute of Technology, Rochester, New York, USA.ORCID https://orcid.org/0000-0002-7211-6745
Randy M StevensCollege of Medicine, St. Christopher's Hospital for Children, Drexel University, Philadelphia, Pennsylvania, USA.
Joseph RossanoDivision of Pediatric Cardiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Vakhtang TchantchaleishviliDivision of Cardiac Surgery, Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-4357-3533
Amy L ThrockmortonBioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-3610-4499

Funding

Multifunctional VAD Technology for High-Risk Pediatric PatientsR01HL153536 · NHLBI · DREXEL UNIVERSITY · PI THROCKMORTON, AMY · 2020 to 2023
$1.6M
NHLBI NIH HHS R01 HL153536NHLBI NIH HHS R01HL153536
6 · The paper itself

Abstract

backgroundMechanical circulatory support (MCS) devices, such as ventricular assist devices (VADs) and total artificial hearts (TAHs), have become a vital therapeutic option in the treatment of end-stage heart failure for adult patients. Such therapeutic options continue to be limited for pediatric patients. Clinicians initially adapted or scaled existing adult devices for pediatric patients; however, these adult devices are not designed to support the anatomical structure and varying flow capacities required for this population and are generally operated "off-design," which risks complications such as hemolysis and thrombosis. Devices designed specifically for the pediatric population which seek to address these shortcomings are now emerging and gaining FDA approval.

methodsTo analyze the competitive landscape of pediatric MCS devices, we conducted a systematic literature review. Approximately 27 devices were studied in detail: 8 were established or previously approved designs, and 19 were under development (11 VADs, 5 Fontan assist devices, and 3 TAHs).

resultsDespite significant progress, there is still no pediatric pump technology that satisfies the unique and distinct design constraints and requirements to support pediatric patients, including the wide range of patient sizes, increased cardiovascular demand with growth, and anatomic and physiologic heterogeneity of congenital heart disease.

conclusionsForward-thinking design solutions are required to overcome these challenges and to ensure the translation of new therapeutic MCS devices for pediatric patients.

Indexed as

Extracorporeal Membrane OxygenationHeart, ArtificialHeart-Assist DevicesHeart FailureChildHumansTechnologymechanical circulatory assistancepediatric blood pumppediatric circulatory supportpediatric total artificial heartpediatric VADpediatric ventricular assist device

Identifiers

PMID35357020
PMCPMC9256769

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.