Evidence map›Paper›PMID 35356902›Full record

ArticleMedicine2022

Comprehensive analysis of expression and prognosis for LMNB family genes in human sarcoma.

Gen Wu, Qunyan Tian, Jie Liu, Qiong Zhou, Dazhi Zou, Ziyuan Chen, Tong Wu, Wanchun Wang, Hong Xia, Jian Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Gen WuDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China,Department of Cardiology, The Fourth Hospital ofChangsha, Changsha, Hunan, China,Department of Spine Surgery, Longhui People's Hospital, Shaoyang, Hunan, China,Department of Orthopedics, The FirstPeople's Hospital of Changde City, Changde, Hunan, China,Department of Emergency, The First Hospital of Changsha City, Changsha, Hunan, China,Departmentof Orthopedics, Xiangtan Central Hospital, Xiangtan, Hunan, China.ORCID 0000-0001-8166-5474
Qunyan Tian
Jie Liu
Qiong Zhou
Dazhi Zou
Ziyuan Chen
Tong Wu
Wanchun Wang
Hong Xia
Jian ZhouORCID 0000-0002-9464-8857
Central South University · CNThe Fourth People's Hospital · CNThe First Hospital of Changsha · CNThe First People's Hospital of Changde · CNXiangyang Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractPrevious studies indicated that lamin proteins were thought to be related to gene expression, chromatin structure, and unclear stability. There are 2 types of vertebrate lamins, including A and B. The 2 B type proteins are encoded by lamin B1 (LMNB1) and lamin B2 (LMNB2). The LMNBs factor has been found to be associated with the development of multiple tumors, but its association with sarcoma has been barely mentioned.The transcription levels of LMNBs were analyzed via Oncomine database. Gene Expression Profiling Interactive Analysis (GEPIA) dataset was adopted to analyze the differential expression of LMNBs in sarcoma. Cancer Cell Line Encyclopedia dataset was used to explore the expression of LMNBs in sarcoma cell line. We analyzed the prognostic value of LMNBs in GEPIA and Kaplan-Meier Plotter. Oncomine and GEPIA datasets were also used to detect the relationship between LMNBs and their co-expressed genes. We used the Database for Annotation, Visualization and Integrated Discovery to conduct the Gene Ontology analysis of LMNBs and their co-expressed genes. Kyoto Encyclopedia of Genes and Genomes was also used to analyze the pathway of LMNBs.LMNB1 and LMNB2 were reported to be hyperexpressed in sarcoma. The expression of LMNBs was elevated in various sarcoma cell lines. According to the results, we observed that LMNBs were connected to the poor overall survival, recurrence-free survival, and disease-free survival of sarcoma patients.This study indicated that hyperexpression of LMNBs was significantly related to worse outcome of sarcoma, LMNB1 and LMNB2 were expected to become potential biomarkers for human.

Indexed as

SarcomaDisease-Free SurvivalGene Expression ProfilingGene OntologyHumansPrognosis

Identifiers

PMID35356902
PMCPMC10513290
OpenAlexW4221004673

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.