Evidence map›Paper›PMID 35356895›Full record

ArticleMolecules and cells2022

Therapeutic Potential of CKD-504, a Novel Selective Histone Deacetylase 6 Inhibitor, in a Zebrafish Model of Neuromuscular Junction Disorders.

Hui Su Jeong, Hye Jin Kim, Deok-Ho Kim, Ki Wha Chung, Byung-Ok Choi, Ji Eun Lee

Open access · diamondAbstract read
In one paragraph

Article in Molecules and cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Hui Su JeongDepartment of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul 06351, Korea.ORCID https://orcid.org/0000-0001-8419-4698
Hye Jin KimDepartment of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul 06351, Korea.ORCID https://orcid.org/0000-0002-7636-3639
Deok-Ho KimDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0002-6989-6074
Ki Wha ChungDepartment of Biological Sciences, Kongju National University, Gongju 32588, Korea.ORCID https://orcid.org/0000-0003-0363-8432
Byung-Ok ChoiDepartment of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul 06351, Korea.ORCID https://orcid.org/0000-0001-5459-1772
Ji Eun LeeDepartment of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul 06351, Korea.ORCID https://orcid.org/0000-0002-4898-741X
Samsung (South Korea) · KRJohns Hopkins University · USKongju National University · KR

Funding

TISSUE ENGINEERED HUMAN NEUROMUSCULAR JUNCTIONS FOR MODELING AXONAL NEUROPATHYR01NS094388 · NINDS · UNIVERSITY OF WASHINGTON · PI KIM, DEOK-HO · 2017 to 2021
$1.7M
NINDS NIH HHS R01 NS094388
6 · The paper itself

Abstract

The neuromuscular junction (NMJ), which is a synapse for signal transmission from motor neurons to muscle cells, has emerged as an important region because of its association with several peripheral neuropathies. In particular, mutations in

Indexed as

Histone Deacetylase 6Neuromuscular Junction DiseasesAnimalsCharcot-Marie-Tooth DiseaseCOVID-19 VaccinesDisease Models, AnimalOrganic ChemicalsVaccines, InactivatedZebrafishZebrafish ProteinsBIBP COVID-19 vaccineCKD-504COVID-19 VaccinesHDAC6 protein, zebrafishHistone Deacetylase 6Organic ChemicalsVaccines, InactivatedZebrafish ProteinsCKD-504GARSHDAC6 inhibitorNeuromuscular JunctionZebrafish

Identifiers

PMID35356895
PMCPMC9001154
OpenAlexW4220679780

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.