SynthesisCartilage
High Prevalence of Pain Sensitization in Knee Osteoarthritis: A Meta-Analysis with Meta-Regression.
Synthesis in Cartilage. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Effects of Non-Immersive Virtual Reality Exercise on Self-Reported Pain and Mechanical Hyperalgesia in Older Adults with Knee and Hip Osteoarthritis: A Secondary Analysis of a Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2025Trial
- The Association of Neuropathic Pain with Function, Disease Severity, Emotional Status, Sleep Disturbance, and Quality of Life in Patients with Knee Osteoarthritis.Journal of clinical medicine · 2026Article
- Clinical phenotypes of neuropathic pain and central sensitization in patients with knee osteoarthritis: demographic data, radiographic severity, and pain intensity.BMC musculoskeletal disorders · 2026Article
- Synovial Fluid Characteristics and Pain Recovery Trajectory Following Rehabilitation in Patients with Meniscal Tears: A Retrospective Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Understanding Pain in Osteoarthritis: A Clinical Framework Based on the Biopsychosocial Model.Topics in geriatric rehabilitation · 2026Article
- Experimental Pain Phenotypes in Individuals With Symptomatic Knee Osteoarthritis: A Neural Network-Based Clustering Approach.Pain research & management · 2026Article
- Review
- Factors associated with pain catastrophizing in patients with knee osteoarthritis: a cross-sectional study.Frontiers in public health · 2026Article
- Longitudinal study of knee pain amongst workers in the Cultural and Psychosocial Influences on Disability (CUPID) study.BMC musculoskeletal disorders · 2025Article
- PainDETECT as a Potential Tool for Personalized Medicine: Predicting Outcome One Year After Knee Arthroplasty.Mayo Clinic proceedings. Innovations, quality & outcomes · 2025Article
- Peripheral neuronal sensitization and neurovascular remodelling in osteoarthritis pain.Nature reviews. Rheumatology · 2025Review
- Potential sources of pain in symptomatic degenerative meniscal tear: A narrative review.Osteoarthritis and cartilage open · 2025Review
- Maladaptive Compensatory Neural Mechanisms Associated with Activity-Related Osteoarthritis Pain: Dissociation of Psychological and Activity-Related Neural Mechanisms of WOMAC Pain and VAS Pain.Journal of clinical medicine · 2025Article
- Factors influencing pain intensity in knee osteoarthritis: a cross-sectional biopsychosocial perspective.BMC musculoskeletal disorders · 2025Article
- A Mediation Appraisal of Neuropathic-like Symptoms, Pain Catastrophizing, and Central Sensitization-Related Signs in Adults with Knee Osteoarthritis-A Cross-Sectional Study.Journal of personalized medicine · 2025Article
- Translational validity of quantitative sensory testing in chronic pain neuro-sensitization: guide of use and interpretation in osteoarthritis animal models.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Safety and efficacy of autologous adipose-derived stem cells for knee osteoarthritis in the elderly population: A systematic review.Journal of clinical orthopaedics and trauma · 2024Review
- Linking Intra-Articular Inflammatory Biomarkers with Peripheral and Central Sensitization in Late-Stage Knee Osteoarthritis Pain: A Pilot Study.Journal of clinical medicine · 2024Article
- Unravelling relationships between obesity, diabetes, and factors related to somatosensory functioning in knee osteoarthritis patients.Clinical rheumatology · 2024Article
- Transcranial Direct Current Stimulation Attenuates the Chronic Pain of Osteoarthritis in Rats via Reducing NMDAR2B Expressions in the Spinal Cord.Journal of musculoskeletal & neuronal interactions · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this meta-analysis was to study the evidence on pain sensitization in knee osteoarthritis (OA), providing a quantitative synthesis of its prevalence and impact. Factors associated with pain sensitization were also investigated.
methodsMeta-analysis; PubMed (MEDLINE), Cochrane Central Register (CENTRAL), and Web of Science were searched on February 2021. Level I to level IV studies evaluating the presence of pain sensitization in patients with symptomatic knee OA, documented through a validated method (questionnaires or quantitative sensory testing), were included. The primary outcome was the prevalence of pain sensitization. Factors influencing the prevalence were also evaluated, as well as differences in terms of pain thresholds between knee OA patients and healthy controls.
resultsFifty-three articles including 7,117 patients were included. The meta-analysis of proportion documented a prevalence of pain sensitization of 20% (95% confidence interval [CI] = 16%-26%) with a significant heterogeneity of results (
conclusionsKnee OA pain presents features that are consistent with a significant degree of pain sensitization. There is a high heterogeneity in the reported results, mainly based on the diagnostic tool used. The identification of the best methods to detect pain sensitization is warranted to correctly evaluate and manage symptoms of patients affected by knee OA. REGISTRATION: PROSPERO CRD42019123347.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.