Evidence map›Paper›PMID 35356822›Full record

ArticleJournal of dental research2022

Human Bone Marrow Stromal Cell Exosomes Ameliorate Periodontitis.

C Yue, J Cao, A Wong, J H Kim, S Alam, G Luong, S Talegaonkar, Z Schwartz, B D Boyan, W V Giannobile and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Journal of dental anesthesia and pain medicine · 2026
    Review
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  7. Article
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  19. Novel approaches for periodontal tissue engineering.Genesis (New York, N.Y. : 2000) · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

C YueDepartment of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA.
J CaoDepartment of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA.
A WongDepartment of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA.
J H KimDepartment of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA.
S AlamDepartment of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA.
G LuongDepartment of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA.
S TalegaonkarDepartment of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA.
Z SchwartzDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA.
B D BoyanDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA.
W V GiannobileDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.ORCID 0000-0002-7102-9746
S E SahingurDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, PA, USA.
Z LinDepartment of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA.
Virginia Commonwealth University · USHarvard University · USUniversity of Pennsylvania · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
Mesenchymal Stem Cell Exosomes for Periodontal RegenerationR03DE027146 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI LIN, ZHAO · 2017 to 2018
$310k
NCI NIH HHS P30 CA016059NIDCR NIH HHS R03 DE027146
6 · The paper itself

Abstract

Human bone marrow stromal cell (hBMSC)-derived exosomes are promising therapeutics for inflammatory diseases due to their unique microRNA (miRNA) and protein cargos. Periodontal diseases often present with chronicity and corresponding exuberant inflammation, which leads to loss of tooth support. In this study, we explored whether hBMSC exosomes can affect periodontitis progression. hBMSC exosomes were isolated from cell culture medium through sequential ultracentrifugation. miRNAs and proteins that were enriched in hBMSC exosomes were characterized by RNA sequencing and protein array, respectively. hBMSC exosomes significantly suppressed periodontal keystone pathogen

Indexed as

ExosomesMesenchymal Stem CellsMicroRNAsPeriodontitisAnimalsHumansInflammationPorphyromonas gingivalisRatsMicroRNAscell therapyexosomesexperimental periodontitishuman bone marrow stromal cellsmiRNAperiodontal inflammation

Identifiers

PMID35356822
PMCPMC9305845
OpenAlexW4220657762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.