ReviewFrontiers in nutrition2022
Mechanistic Impact of Zinc Deficiency in Human Development.
Review in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- Zinc-Induced Hematologic Toxicities: A Systematic Review of Descriptive Studies.Biological trace element research · 2026Pooled it
- Iron and Other Metal Ions in Human Health and Disease.MedComm · 2026Review
- Article
- Point mutation in zinc sensor causes a threefold zinc level increase in Sorghum bicolor.The New phytologist · 2026Article
- Feeding the Future: Next-Generation Nutritional Frontiers-Innovations, Technologies, and Transformative Pathways for Sustainable Global Food Systems.Food science & nutrition · 2026Review
- Health risk assessment and ionomic profiling under cadmium, lead, zinc, and manganese stress in Amaranthus cruentus.BMC plant biology · 2026Article
- Biofortifying sunflower with Zinc (Zn) aminochelates: a promising strategy for calcareous soil conditions.BMC plant biology · 2026Article
- Association of maternal multiple serum metal/metalloid concentrations and metabolic gene polymorphisms with offspring skeletal defects: a multicenter case-control study.BMC pregnancy and childbirth · 2026Article
- Synergistic effects ofFrontiers in nutrition · 2026Article
- Co-inoculation of endophytic bacteria enhances hydroponic wheat performance and zinc biofortification through root exudates modulation.Frontiers in microbiology · 2026Article
- Mechanistic Insights into Antioxidant Interventions Targeting Obesity-Induced Oxidative Stress in the Pathogenesis and Complications of Type 2 Diabetes Mellitus.Current issues in molecular biology · 2025Review
- Development of a zinc-enriched yeast strain for nutritional applications using low-cost ingredients.Scientific reports · 2025Article
- Assessment of Heavy Metal Accumulation in Wastewater-Receiving Soil-Exotic and Indigenous Vegetable Systems and Its Potential Health Risks: A Case Study from Blantyre, Malawi.International journal of environmental research and public health · 2025Article
- Zinc-Mediated Defenses Against Toxic Heavy Metals and Metalloids: Mechanisms, Immunomodulation, and Therapeutic Relevance.International journal of molecular sciences · 2025Review
- Optimizing Agronomic Zinc Biofortification in Carrots.Plant-environment interactions (Hoboken, N.J.) · 2025Article
- Empowering health with mushroom biofortification: nutritional and medicinal attributes.Journal of food science and technology · 2025Review
- Preparation, Characterization, and In Vitro Stability Analysis of Deer Sinew Peptide-Zinc Chelate.Foods (Basel, Switzerland) · 2025Article
- Nutrient Intake Adequacy among Adults in Indonesia and Malaysia: A Systematic Review and Meta-Analysis.Current developments in nutrition · 2025Review
- The interplay between oxidative stress, zinc, and metabolic dysfunction in polycystic ovarian syndrome.Molecular and cellular biochemistry · 2025Review
- Assessment of the bioaccessibility of zinc in the selected biofortified food grains.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc (Zn) deficiency in humans is an emerging global health issue affecting approximately two billion people across the globe. The situation prevails due to the intake of Zn deficient grains and vegetables worldwide. Clinical identification of Zn deficiency in humans remains problematic because the symptoms do not appear until impair the vital organs, such as the gastrointestinal track, central nervous system, immune system, skeletal, and nervous system. Lower Zn body levels are also responsible for multiple physiological disorders, such as apoptosis, organs destruction, DNA injuries, and oxidative damage to the cellular components through reactive oxygen species (ROS). The oxidative damage causes chronic inflammation lead toward several chronic diseases, such as heart diseases, cancers, alcohol-related malady, muscular contraction, and neuro-pathogenesis. The present review focused on the physiological and growth-related changes in humans under Zn deficient conditions, mechanisms adopted by the human body under Zn deficiency for the proper functioning of the body systems, and the importance of nutritional and nutraceutical approaches to overcome Zn deficiency in humans and concluded that the biofortified food is the best source of Zn as compared to the chemical supplementation to avoid their negative impacts on human.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.