ArticleResearch and practice in thrombosis and haemostasis2022
Platelet reactivity and platelet count in women with iron deficiency treated with intravenous iron.
Article in Research and practice in thrombosis and haemostasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07083583 (Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders: a Single-arm Prospective Observational Study
Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Adjudication of Hospitalizations and Deaths in the IRONMAN Trial of Intravenous Iron for Heart Failure.Journal of the American College of Cardiology · 2024Trial
- Pregnancy Outcomes Associated With Anemia in the First Trimester and Anemia Resolution by Late Pregnancy.Obstetrics and gynecology · 2026Article
- Platelet to lymphocyte ratio in the healthy population of Vojvodina.Journal of medical biochemistry · 2026Article
- Coagulation abnormalities in pediatric anemia clinical and laboratory correlates for risk stratification and risk assessment.Annals of medicine and surgery (2012) · 2026Review
- Prevalence of iron deficiency in patients with mild to moderate bleeding disorders and bleeding disorder of unknown cause.Research and practice in thrombosis and haemostasis · 2025Article
- Association between iron deficiency anemia and risk of hearing loss among female patients: a multi-institutional cohort study.Frontiers in nutrition · 2025Article
- Perinatal Outcomes Following Intravenous Iron for Treatment of Iron Deficiency With and Without Anemia.European journal of haematology · 2024Article
- Management of abnormal uterine bleeding on anticoagulation: the patient-clinician perspective.Journal of thrombosis and haemostasis : JTH · 2024Review
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- Laboratory-based inequity in thrombosis and hemostasis: review of the evidence.Research and practice in thrombosis and haemostasis · 2023Review
- Markers of Oxidative Stress, Inflammation and Endothelial Function following High-Dose Intravenous Iron in Patients with Non-Dialysis-Dependent Chronic Kidney Disease-A Pooled Analysis.International journal of molecular sciences · 2022Article
- Platelet reactivity and platelet count in women with iron deficiency treated with intravenous iron.Research and practice in thrombosis and haemostasis · 2022Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Background: Iron deficiency anemia (IDA) and heavy menstrual bleeding are prevalent, interrelated issues impacting over 300 million premenopausal women worldwide. IDA is generally associated with increased platelet counts; however, the effects of IDA and its correction on platelet function in premenopausal women remain unknown. Objectives: We sought to determine how IDA and intravenous iron affect platelet count and platelet function in premenopausal women. Methods: Hematologic indices were assessed in a multicenter, retrospective cohort of 231 women repleted with intravenous iron. Pre- and postinfusion blood samples were then obtained from a prospective cohort of 13 women to analyze the effect of intravenous iron on hematologic parameters as well as platelet function with flow cytometry and platelet aggregation assays under physiologic shear. Results: Following iron replacement, anemia improved, and mean platelet counts decreased by 26.5 and 16.0 K/mm Conclusion: We find that intravenous iron improves anemia while restoring platelet counts and platelet secretory responses in premenopausal women with iron deficiency. Our results suggest that iron deficiency as well as iron replacement can have a range of effects on platelet production and function. Consequently, platelet reactivity profiles should be further examined in women and other groups with IDA where replacement offers a promising means to improve anemia as well as quality of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.