SynthesisFrontiers in aging neuroscience2022
Risk of Dementia or Cognitive Impairment in Sepsis Survivals: A Systematic Review and Meta-Analysis.
Synthesis in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 7 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Pooled it
- A Systematic Review of Semaglutide's Influence on Cognitive Function in Preclinical Animal Models and Cell-Line Studies.International journal of molecular sciences · 2024Pooled it
- Pooled it
- Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies.Annals of medicine · 2023Pooled it
- Risk of dry eye in headache patients: a systematic review and meta-analysis.Annals of medicine · 2022Pooled it
- Prevalence of sepsis among adults in China: A systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- Risk of Dementia or Cognitive Impairment in Sepsis Survivals: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2022Pooled it
- Cognitive Health and Quality of Life After Surviving Sepsis: A Narrative Review.Journal of intensive care medicine · 2026Review
- Long-term risk of dementia following encephalitis: a large-scale retrospective cohort study of electronic health records.Journal of neurology · 2026Article
- Trajectories of sepsis survivors in Australia: A scoping review.Journal of the Intensive Care Society · 2026Article
- Development and external validation of a 90-day mortality prediction model for comatose sepsis patients: impact of cerebrovascular disease and dementia.Frontiers in medicine · 2026Article
- Metabolic reprogramming in sepsis-associated encephalopathy: emerging mechanisms, candidate biomarkers, and future therapeutic directions.Frontiers in medicine · 2026Review
- Bloodstream Infection-induced Neuroinflammation: from Systemic Infection To Brain Invasion.Current microbiology · 2025Review
- The Crosstalk Between Sepsis-Associated Encephalopathy and Alzheimer's Disease: Identifying Potential Biomarkers and Therapeutic Targets for Cognition.Molecular neurobiology · 2025Article
- Frontal, temporal, cerebellar changes link to sepsis survivors' cognitive issues: A resting state functional magnetic resonance imaging study.World journal of psychiatry · 2025Article
- Artificial intelligence approach to optimise safety for hospitalised patients with dementia.BMJ open quality · 2025Article
- Temporal impact of sepsis on Alzheimer's disease pathology and neuroinflammation.Progress in neurobiology · 2025Article
- Editorial for the Special Issue "Aging, Age-Related Changes in the Brain and the Progression of Alzheimer's Disease".Current issues in molecular biology · 2025Article
- Postoperative sepsis and its sequential impact on dementia.Critical care (London, England) · 2025Article
- Neuroinflammation: A Driving Force in the Onset and Progression of Alzheimer's Disease.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There is growing evidence that sepsis survivors are at increased risk of developing new-onset atrial fibrillation, acute kidney injury, and neurological diseases. However, whether sepsis survivals increase the risk of dementia or cognitive impairment remains to be further explored. Objective: The objective of this study was to determine whether sepsis survivals increase the risk of dementia or cognitive impairment. Methods: We searched PubMed, Cochrane Library, Web of Science, and EMBASE databases for cohort studies or case-control studies from their inception to November 5, 2021. The quality of this study was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). The Stata software (version 15.1) was used to calculate the odds ratio (OR) of dementia or cognitive impairment in sepsis survivals. Subgroup and sensitivity analyses were performed to assess the source of heterogeneity. Funnel plots and Egger's test were used to detect the publication bias. Results: Eight studies (i.e., seven cohort studies and one case-control study) involving 891,562 individuals were included. The quality assessment results showed that the average score of NOS was over 7, and the overall quality of the included studies was high. Pooled analyses indicated that sepsis survivals were associated with an increased risk of all-cause dementia (OR = 1.62, 95% CI = 1.23-2.15, Conclusion: Sepsis survivals are associated with an increased risk of all-cause dementia but not with cognitive impairment. Appropriate management and prevention are essential to preserve the cognitive function of sepsis survivors and reduce the risk of dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.