ArticleJournal of pain research2022
Anti-Inflammatory and Antinociceptive Effects of
Article in Journal of pain research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Chinese ginger (Boesenbergia rotunda) mitigates diabetic nephropathy and cardiomyopathy by regulating oxidative inflammatory pathway.Journal of molecular histology · 2025Article
- The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats.Purinergic signalling · 2025Article
- Potential Cutaneous Applications ofInternational journal of molecular sciences · 2025Article
- Traditional usages, chemical metabolites, pharmacological activities, and pharmacokinetics ofFrontiers in pharmacology · 2025Review
- Efficient Simultaneous Isolation of Pinostrobin and Panduratin A fromMolecules (Basel, Switzerland) · 2024Article
- Review
- Ginger alleviates mechanical hypersensitivity and anxio-depressive behavior in rats with diabetic neuropathy through beneficial actions on gut microbiome composition, mitochondria, and neuroimmune cells of colon and spinal cord.Nutrition research (New York, N.Y.) · 2024Article
- Boesenbergia rotunda displayed anti-inflammatory, antioxidant and anti-apoptotic efficacy in doxorubicin-induced cardiotoxicity in rats.Scientific reports · 2023Article
- Dehydrozingerone Alleviates Hyperalgesia, Oxidative Stress and Inflammatory Factors in Complete Freund's Adjuvant-Induced Arthritic Rats.Drug design, development and therapy · 2022Article
- ViphyllinDiabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Diabetic peripheral neuropathy (DPN) is still one of the most prevailing complication of diabetes and it affects a huge diabetic population. Methods: DPN was induced in male Sprague Dawley rats using a combination of 30% fructose solution and streptozotocin (40 mg/kg). Afterwards diabetic rats were treated with EBR (100 and 400 mg/kg) for 5 weeks. DPN was assessed using thermal hyperalgesia, cold and mechanical allodynia and rotarod test, while nociceptive responses were assessed by formalin and acetic acid test. In addition, serum proinflammatory cytokine levels were determined using ELISA kits. Results: EBR displayed hypoglycemic effect by significantly reducing the blood glucose concentration of treated diabetic rats, while simultaneously alleviating the reduced body weight. Furthermore, EBR markedly alleviated thermal hyperalgesia, cold and mechanical allodynic responses as well as ameliorated motor coordination in the treated diabetic rats. In addition, EBR significantly reduced nociceptive responses in the formalin and acetic acid test, as well as decreased serum levels of proinflammatory cytokines (TNF-α and IL-1β). Conclusion: The results suggested that EBR exerted anti-inflammatory and anti-nociceptive effects, thus alleviating diabetic painful neuropathy.
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