Evidence map›Paper›PMID 35356147›Full record

ReviewFrontiers in endocrinology2021

Assessment of the Emerging Threat Posed by Perfluoroalkyl and Polyfluoroalkyl Substances to Male Reproduction in Humans.

Leah Calvert, Mark P Green, Geoffry N De Iuliis, Matthew D Dun, Brett D Turner, Bradley O Clarke, Andrew L Eamens, Shaun D Roman, Brett Nixon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leah CalvertPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, Newcastle, NSW, Australia.
Mark P GreenSchool of BioSciences, Faculty of Science, University of Melbourne, VIC, Australia.
Geoffry N De IuliisPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, Newcastle, NSW, Australia.
Matthew D DunHunter Medical Research Institute, New Lambton Heights, Newcastle NSW, Australia.
Brett D TurnerCentre for Technology in Water and Wastewater, School of Civil and Environmental Engineering, University of Technology Sydney, Ultimo, Sydney, NSW, Australia.
Bradley O ClarkeAustralian Laboratory for Emerging Contaminants, School of Chemistry, University of Melbourne, Melbourne, VIC, Australia.
Andrew L EamensPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, Newcastle, NSW, Australia.
Shaun D RomanPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, Newcastle, NSW, Australia.
Brett NixonPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, Newcastle, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Per-fluoroalkyl and polyfluoroalkyl substances (PFAS) are a diverse group of synthetic fluorinated chemicals used widely in industry and consumer products. Due to their extensive use and chemical stability, PFAS are ubiquitous environmental contaminants and as such, form an emerging risk factor for male reproductive health. The long half-lives of PFAS is of particular concern as the propensity to accumulate in biological systems prolong the time taken for excretion, taking years in many cases. Accordingly, there is mounting evidence supporting a negative association between PFAS exposure and an array of human health conditions. However, inconsistencies among epidemiological and experimental findings have hindered the ability to definitively link negative reproductive outcomes to specific PFAS exposure. This situation highlights the requirement for further investigation and the identification of reliable biological models that can inform health risks, allowing sensitive assessment of the spectrum of effects of PFAS exposure on humans. Here, we review the literature on the biological effects of PFAS exposure, with a specific focus on male reproduction, owing to its utility as a sentinel marker of general health. Indeed, male infertility has increasingly been shown to serve as an early indicator of a range of co-morbidities such as coronary, inflammatory, and metabolic diseases. It follows that adverse associations have been established between PFAS exposure and the incidence of testicular dysfunction, including pathologies such as testicular cancer and a reduction in semen quality. We also give consideration to the mechanisms that render the male reproductive tract vulnerable to PFAS mediated damage, and discuss novel remediation strategies to mitigate the negative impact of PFAS contamination and/or to ameliorate the PFAS load of exposed individuals.

Indexed as

FluorocarbonsNeoplasms, Germ Cell and EmbryonalTesticular NeoplasmsHumansMaleReproductionSemen AnalysisFluorocarbonsmale fertilitymale infertilitymale reproductionperfluoroalkyl and polyfluoroalkyl substancesPFASspermtoxicants

Identifiers

PMID35356147
PMCPMC8959433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.