Evidence map›Paper›PMID 35356087›Full record

ArticlePPAR research2022

Explore the Role of the rs1801133-PPARG Pathway in the H-type Hypertension.

Xiuwen Liang, Tingting He, Lihong Gao, Libo Wei, Di Rong, Yu Zhang, Yu Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PPAR research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xiuwen Liang *Cardiology Department, Hulunbeir China Mongolia Hospital Affiliated to the Teaching Hospital of Inner Mongolia Medical University, No. 58 West Street, Hailar District, Hulunbuir, Inner Mongolia 021000, China.ORCID https://orcid.org/0000-0003-3567-2037
Tingting He *Cardiology Department, Hulunbeir People's Hospital, No. 20, Shengli Street, Hailar District, Hulunbuir, Inner Mongolia 021008, China.ORCID https://orcid.org/0000-0002-1419-3160
Lihong GaoNeurology Department, Hulunbeir People's Hospital, No. 20, Shengli Street, Hailar District, Hulunbuir, Inner Mongolia 021008, China.ORCID https://orcid.org/0000-0003-3715-3505
Libo WeiCardiology Department, Inner Mongolia Medical University, No. 5 Xinhua Street, Huimin District, Hohhot, Inner Mongolia 010110, China.ORCID https://orcid.org/0000-0002-8597-0967
Di RongGeriatric Department, Hulunbeir People's Hospital, No. 20, Shengli Street, Hailar District, Hulunbuir, Inner Mongolia 021008, China.ORCID https://orcid.org/0000-0001-7952-1113
Yu ZhangCardiology Department, Inner Mongolia Minzu University, No. 536, West Huolinhe Street, Tongliao, Inner Mongolia 028000, China.ORCID https://orcid.org/0000-0003-3329-3324
Yu LiuCardiology Department, Inner Mongolia Minzu University, No. 536, West Huolinhe Street, Tongliao, Inner Mongolia 028000, China.ORCID https://orcid.org/0000-0001-8872-1619
Hulunbuir University · CNMinzu University of China · CNInner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both rs1801133 mutation on Methylenetetrahydrofolate reductase (MTHFR) gene and transcription factor peroxisome proliferator-activated gamma (PPARG) have been associated with plasma homocysteine (Hcy) levels and hypertension. However, their role in H-type hypertension remains unclear. In this study, we first tested the association between rs1801133 genotypes and Hcy level in H-type hypertension using clinical profiles collected from 203 patients before and after the treatment using enalapril maleate and folic acid tablets (EMFAT). Then, we constructed a literature-based pathway analysis to explore the role of the rs1801133-PPARG signaling pathway in H-type hypertension and its treatment. Although presented similar blood pressure, the patients with TT genotype of rs1801133 were much younger (

Identifiers

PMID35356087
PMCPMC8958104
OpenAlexW4221089508

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.