Evidence map›Paper›PMID 35356081›Full record

ReviewFrontiers in physiology2022

The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia.

Yukun Li, Xiaodong Peng, Rong Lin, Xuesi Wang, Xinmeng Liu, Rong Bai, Changsheng Ma, Ribo Tang, Yanfei Ruan, Nian Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Yukun LiDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Xiaodong PengDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Rong LinNorth China Medical and Health Group XingTai Hospital, Xingtai, China.
Xuesi WangDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Xinmeng LiuDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Rong BaiBanner - University Medical Center Phoenix, University of Arizona College of Medicine, Phoenix, AZ, United States.
Changsheng MaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Ribo TangDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Yanfei RuanDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Nian LiuDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
National Clinical Research Center for Digestive Diseases · CNBeijing Anzhen Hospital · CNBanner - University Medical Center Phoenix · USCapital Medical University · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe yet rare inherited arrhythmia disorder. The cornerstone of CPVT medical therapy is the use of β-blockers; 30% of patients with CPVT do not respond well to optimal β-blocker treatment. Studies have shown that flecainide effectively prevents life-threatening arrhythmias in CPVT. Flecainide is a class IC antiarrhythmic drug blocking cardiac sodium channels. RyR2 inhibition is proposed as the principal mechanism of antiarrhythmic action of flecainide in CPVT, while it is highly debated. In this article, we review the current progress of this issue.

Indexed as

antiarrhythmic mechanismcatecholaminergic polymorphic ventricular tachycardiaflecainideryanodine receptorsodium channel

Identifiers

PMID35356081
PMCPMC8959698
OpenAlexW4221093914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.