Evidence map›Paper›PMID 35356065›Full record

ArticleDisease markers2022

Elevated Serum IGFBP-2 and CTGF Levels Are Associated with Disease Activity in Patients with Dermatomyositis.

Min Yang, Yuehong Chen, Geng Yin, Sang Lin, Huan Liu, Yupeng Huang, Yunru Tian, Yueyuan Zhou, Fengming Luo, Qibing Xie

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Min Yang *Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0000-0003-2444-4194
Yuehong Chen *Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0000-0003-1948-6867
Geng YinDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sang LinDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Huan LiuDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Yupeng HuangDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Yunru TianDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Yueyuan ZhouDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Fengming LuoDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu 610041, China.ORCID https://orcid.org/0000-0001-9267-3437
Qibing XieDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0000-0002-6727-1839
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Insulin-like growth factor-binding proteins (IGFBPs) and connective tissue growth factor (CTGF) participate in angiogenesis. Dermatomyositis (DM) is characterized by microvasculopathy-derived skin lesions. Here, we investigated the clinical significance of serum IGFBP and CTGF levels in DM patients. Methods: In this study, 65 DM patients and 30 healthy controls were enrolled. Serum IGFBP and CTGF levels were examined by ELISA, and their correlation with clinical and laboratory findings was analyzed by Spearman's correlation. Results: Serum IGFBP-2, IGFBP-4, and CTGF levels were higher in DM patients than in healthy controls (median (quartile): 258.9 (176.4-326.1) ng/mL vs. 167.7 (116.1-209.4) ng/mL, Conclusion: Serum IGFBP-2 and CTGF levels were increased in patients with DM and correlated with cutaneous and global disease activity.

Indexed as

DermatomyositisInsulin-Like Growth Factor Binding Protein 2Connective Tissue Growth FactorHumansInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IConnective Tissue Growth FactorInsulin-Like Growth Factor Binding Protein 2Insulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor I

Identifiers

PMID35356065
PMCPMC8958080
OpenAlexW4220865191

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.