ArticleBrain communications2022
Tau and the fractionated default mode network in atypical Alzheimer's disease.
Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 33 citations in OpenAlex.
- Resting-state functional and spectral alterations underlying cognitive decline in biomarker-confirmed Alzheimer's disease: A systematic review.NeuroImage. Clinical · 2026Article
- Improving the clinical trial landscape for patients with atypical variants of Alzheimer's disease: a call to action.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Longitudinal trajectories of divergent cortical tau patterns in preclinical Alzheimer's disease.Brain : a journal of neurology · 2026Article
- Pretangle tau pathology accrual in the default mode network during the progression of Alzheimer's disease.Molecular neurodegeneration advances · 2026Article
- Multimodal brain network disruption and structural-functional decoupling in overt hypothyroidism.Frontiers in endocrinology · 2026Article
- Functional network contributions to longitudinal tau spread in Posterior Cortical Atrophy.NPJ dementia · 2026Article
- A Functional Resting-State Network Atlas Based on 420 Older Adults with Hypertension.bioRxiv : the preprint server for biology · 2025Article
- Poor dream recall associates with Alzheimer's disease biomarkers and dementia risk.medRxiv : the preprint server for health sciences · 2025Article
- Neural mechanisms of disease pathology and cognition in young-onset Alzheimer's disease variants.Journal of Alzheimer's disease : JAD · 2025Article
- Alterations of brain white matter network topological properties in overt hypothyroidism.Endocrine connections · 2025Article
- Default mode network tau predicts future clinical decline in atypical early Alzheimer's disease.Brain : a journal of neurology · 2025Article
- Biomarkers of blood-brain barrier and neurovascular unit integrity in human cognitive impairment and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer's disease: a neuropsychological data-driven approach.Alzheimer's research & therapy · 2025Article
- Associations of tau, Aβ, and brain volume of the Papez circuit with cognition in Alzheimer's disease.European archives of psychiatry and clinical neuroscience · 2025Article
- Cortical morphology changes in default mode network regions as predictors of cognitive decline in relation to amyloid and tau deposits.Brain communications · 2025Article
- Altered brain connectivity in mild cognitive impairment is linked to elevated tau and phosphorylated tau, but not to GAP-43 and Amyloid-β measurements: a resting-state fMRI study.Molecular brain · 2024Article
- Early detection of dementia with default-mode network effective connectivity.Nature. Mental health · 2024Article
- Data-driven decomposition and staging of flortaucipir uptake in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Default mode network tau predicts future clinical decline in atypical early Alzheimer's disease.medRxiv : the preprint server for health sciences · 2024Article
- Altered structural and functional connectivity in Posterior Cortical Atrophy and Dementia with Lewy bodies.NeuroImage · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Alzheimer's disease-related atrophy in the posterior cingulate cortex, a key node of the default mode network, is present in the early stages of disease progression across clinical phenotypic variants of the disease. In the typical amnestic variant, posterior cingulate cortex neuropathology has been linked with disrupted connectivity of the posterior default mode network, but it remains unclear if this relationship is observed across atypical variants of Alzheimer's disease. In the present study, we first sought to determine if tau pathology is consistently present in the posterior cingulate cortex and other posterior nodes of the default mode network across the atypical Alzheimer's disease syndromic spectrum. Second, we examined functional connectivity disruptions within the default mode network and sought to determine if tau pathology is related to functional disconnection within this network. We studied a sample of 25 amyloid-positive atypical Alzheimer's disease participants examined with high-resolution MRI, tau (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.