Evidence map›Paper›PMID 35356016›Full record

ArticleFrontiers in public health2022

Rabies Elimination in Rural Kenya: Need for Improved Availability of Human Vaccines, Awareness and Knowledge on Rabies and Its Management Among Healthcare Workers.

Veronicah Mbaire Chuchu, Philip Mwanzia Kitala, Philet Bichanga, Daniel Ksee, Mathew Muturi, Athman Mwatondo, Carolyne Nasimiyu, Marybeth Maritim, Nyamai Mutono, Tariku J Beyene and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 4 countries.

Veronicah Mbaire ChuchuDepartment of Public Health, Pharmacology and Toxicology, University of Nairobi, Nairobi, Kenya.
Philip Mwanzia KitalaDepartment of Public Health, Pharmacology and Toxicology, University of Nairobi, Nairobi, Kenya.
Philet BichangaGovernment of Makueni County, Department of Health Services, Wote, Kenya.
Daniel KseeGovernment of Makueni County, Department of Agriculture, Irrigation, Livestock, and Fisheries Development, Wote, Kenya.
Mathew MuturiZoonotic Disease Unit, Ministry of Health and Ministry of Agriculture, Livestock and Fisheries, Nairobi, Kenya.
Athman MwatondoZoonotic Disease Unit, Ministry of Health and Ministry of Agriculture, Livestock and Fisheries, Nairobi, Kenya.
Carolyne NasimiyuWashington State University Global Health Program, Nairobi, Kenya.
Marybeth MaritimDepartment of Clinical Medicine and Therapeutics, University of Nairobi, Nairobi, Kenya.
Nyamai MutonoWashington State University Global Health Program, Nairobi, Kenya.
Tariku J BeyeneCenter for Health Equity and Outcomes Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.
Sophie DruellesVaccine Epidemiology and Modeling, Sanofi Pasteur, Lyon, France.
Katie HampsonInstitute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow, United Kingdom.
S M ThumbiCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
University of Nairobi · KEMinistry of Agriculture Livestock and Fisheries · KEKenya School of Government · KEMinistry of Health · KENationwide Children's Hospital · USSanofi (France) · FRUniversity of Glasgow · GBWashington State Department of Health · USWashington State University · US

Funding

Zoonotic and Emerging Infectious Diseases Training ProgramD43TW011519 · FIC · WASHINGTON STATE UNIVERSITY · PI Walter Godfrey Jaoko, Thumbi Mwangi · 2020 to 2026
$1.2M
FIC NIH HHS D43 TW011519Wellcome Trust 110330/Z/15/ZWellcome Trust 207569/Z/17/Z
6 · The paper itself

Abstract

Background: In Africa, rabies causes an estimated 24,000 human deaths annually. Mass dog vaccinations coupled with timely post-exposure prophylaxis (PEP) for dog-bite patients are the main interventions to eliminate human rabies deaths. A well-informed healthcare workforce and the availability and accessibility of rabies biologicals at health facilities are critical in reducing rabies deaths. We assessed awareness and knowledge regarding rabies and the management of rabies among healthcare workers, and PEP availability in rural eastern Kenya. Methodology: We interviewed 73 healthcare workers from 42 healthcare units in 13 wards in Makueni and Kibwezi West sub-counties, Makueni County, Kenya in November 2018. Data on demographics, years of work experience, knowledge of rabies, management of bite and rabies patients, and availability of rabies biologicals were collected and analyzed. Results: Rabies PEP vaccines were available in only 5 (12%) of 42 health facilities. None of the health facilities had rabies immunoglobulins in stock at the time of the study. PEP was primarily administered intramuscularly, with only 11% ( Conclusion: The availability and use of PEP for rabies was sub-optimal. We identified two urgent needs to support rabies elimination programmes: improving availability and access to PEP; and targeted training of the healthcare workers to improve awareness on bite wound management, judicious use of PEP including appropriate risk assessment following bites and the use of the dose-sparing intradermal route in facilities seeing multiple bite patients. Global and domestic funding plan that address these gaps in the human health sector is needed for efficient rabies elimination in Africa.

Indexed as

Disease EradicationHealth Services Needs and DemandRabiesRural HealthAnimalsBites and StingsDog DiseasesDogsHealth Knowledge, Attitudes, PracticeHealth PersonnelHumansKenyaMass VaccinationPost-Exposure ProphylaxisRabies VaccinesRabies Vaccinesawarenessknowledgepost-exposure-prophylaxisrabiesrabies immunoglobulin

Identifiers

PMID35356016
PMCPMC8960031
OpenAlexW4220901493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.