Evidence map›Paper›PMID 35355987›Full record

ArticleFrontiers in immunology2022

T-Cell Responses to Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses to the Colorectal Cancer Antigen, Guanylyl Cyclase C.

John C Flickinger, Jagmohan Singh, Yanki Yarman, Robert D Carlson, Joshua R Barton, Scott A Waldman, Adam E Snook

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Mathematical Modeling ofBioengineering (Basel, Switzerland) · 2025
    Article
  4. Recent Advances in Host Immune Mechanisms AgainstJournal of inflammation research · 2025
    Review
  5. Article
  6. Article
  7. Frontiers in immunology · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

John C FlickingerDepartment of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, United States.
Jagmohan SinghDepartment of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, United States.
Yanki YarmanDepartment of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, United States.
Robert D CarlsonDepartment of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, United States.
Joshua R BartonDepartment of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, United States.
Scott A WaldmanDepartment of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, United States.
Adam E SnookDepartment of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, United States.
Thomas Jefferson University · USSidney Kimmel Cancer Center · US

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Andrew Chapman · 1995 to 2026
$94.8M
Guanylin GUCY2C axis in Colorectal Cancer InitiationR01CA204481 · NCI · THOMAS JEFFERSON UNIVERSITY · PI WALDMAN, SCOTT A · 2017 to 2021
$1.8M
(PQ1) GUCY2C hormone loss translates APC-Beta-catenin mutations into epithelial transformationR01CA206026 · NCI · THOMAS JEFFERSON UNIVERSITY · PI WALDMAN, SCOTT A · 2016 to 2020
$1.8M
Training Program in Cancer BiologyT32CA236736 · NCI · THOMAS JEFFERSON UNIVERSITY · PI APLIN, ANDREW ERIC, LANGUINO, LUCIA R. · 2019 to 2023
$1.1M
Silencing the uroguanylin-GUCY2C gut-brain axis mediates leptin resistance in obesityF30DK127639 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI BARTON, JOSHUA R · 2020 to 2024
$175k
NCI NIH HHS P30 CA056036NCI NIH HHS R01 CA204481NCI NIH HHS R01 CA206026NCI NIH HHS T32 CA236736NIDDK NIH HHS F30 DK127639
6 · The paper itself

Abstract

The Gram-positive bacterium

Indexed as

Cancer VaccinesColorectal NeoplasmsListeriaListeria monocytogenesEpitopesHumansImmunodominant EpitopesPeptidesReceptors, EnterotoxinCancer VaccinesEpitopesGUCY2C protein, humanImmunodominant EpitopesPeptidesReceptors, Enterotoxincolorectal cancerGUCY2Cimmunodominancelisteriavaccine

Identifiers

PMID35355987
PMCPMC8959893
OpenAlexW4220680079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.