Evidence map›Paper›PMID 35355984›Full record

ArticleFrontiers in immunology2022

The Icarus Flight of Perinatal Stem and Renal Progenitor Cells Within Immune System.

Angela Picerno, Giuseppe Castellano, Claudia Curci, Katarzyna Kopaczka, Alessandra Stasi, Giovanni Battista Pertosa, Carlo Sabbà, Loreto Gesualdo, Roberto Gramignoli, Fabio Sallustio

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Angela PicernoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Giuseppe CastellanoNephrology, Dialysis and Renal Transplant Unit, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Claudia CurciNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation (DETO), University of Bari Aldo Moro, Bari, Italy.
Katarzyna KopaczkaDepartment of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden.
Alessandra StasiNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation (DETO), University of Bari Aldo Moro, Bari, Italy.
Giovanni Battista PertosaNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation (DETO), University of Bari Aldo Moro, Bari, Italy.
Carlo SabbàDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Loreto GesualdoNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation (DETO), University of Bari Aldo Moro, Bari, Italy.
Roberto GramignoliDepartment of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden.
Fabio SallustioDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
University of Bari Aldo Moro · ITKarolinska Institutet · SEUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our immune system actively fights bacteria and viruses, and it must strike a delicate balance between over- and under-reaction, just like Daedalus and Icarus in Greek mythology, who could not escape their imprisonment by flying too high or too low. Both human amniotic epithelial and mesenchymal stromal cells and the conditioned medium generated from their culture exert multiple immunosuppressive activities. They have strong immunomodulatory properties that are influenced by the types and intensity of inflammatory stimuli present in the microenvironment. Notably, very recently, the immunomodulatory activity of human adult renal stem/progenitor cells (ARPCs) has been discovered. ARPCs cause a decrease in Tregs and CD3

Indexed as

Mesenchymal Stem CellsAdultAnimalsHumansImmunomodulationInflammationStem CellsT-Lymphocytesimmune systemimmunomodulationinflammatory responseperinatal stem cellsrenal stem cellsstem cellsT cells

Identifiers

PMID35355984
PMCPMC8959820
OpenAlexW4221011076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.