Evidence map›Paper›PMID 35355982›Full record

ArticleFrontiers in immunology2022

Improvement of Lipoplexes With a Sialic Acid Mimetic to Target the C1858T

Andrea Arena, Eugenia Belcastro, Francesca Ceccacci, Stefania Petrini, Libenzio Adrian Conti, Olivia Pagliarosi, Ezio Giorda, Simona Sennato, Riccardo Schiaffini, Peng Wang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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  6. The Putative Role ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Andrea ArenaInfectivology and Clinical Trials Research Department, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Eugenia BelcastroInfectivology and Clinical Trials Research Department, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Francesca CeccacciCentro Nazionale Ricerche Institute for Biological Systems (CNR -ISB), Secondary Office of Rome-Reaction Mechanisms c/o Department of Chemistry, Sapienza University, Rome, Italy.
Stefania PetriniResearch Laboratories, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Libenzio Adrian ContiResearch Laboratories, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Olivia PagliarosiInfectivology and Clinical Trials Research Department, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Ezio GiordaResearch Laboratories, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Simona SennatoCNR Institute for Complex Systems, Secondary Office of Rome c/o Department of Physics, Sapienza University Rome, Rome, Italy.
Riccardo SchiaffiniDiabetes and Growth Pathology Unit, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Peng WangDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States.
James C PaulsonDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Giovanna ManciniCentro Nazionale Ricerche Institute for Biological Systems (CNR-ISB), Area della Ricerca di Roma 1, Monterotondo, Italy.
Alessandra FierabracciInfectivology and Clinical Trials Research Department, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Bambino Gesù Children's Hospital · ITInstitute for Complex Systems · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITScripps Research Institute · US

Funding

Exploiting inhibitory Siglecs for desensitizing mast cellsR01AI132790 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI PAULSON, JAMES C · 2018 to 2022
$3.1M
NIAID NIH HHS R01 AI132790
6 · The paper itself

Abstract

The C1858T variant of the protein tyrosine phosphatase N22 (

Indexed as

Diabetes Mellitus, Type 1Protein Tyrosine Phosphatase, Non-Receptor Type 22AutoimmunityHumansImmunologic FactorsImmunotherapyLeukocytes, MononuclearN-Acetylneuraminic AcidPhosphoric Monoester HydrolasesRNA, Small InterferingSialic Acid Binding Immunoglobulin-like LectinsImmunologic FactorsN-Acetylneuraminic AcidPhosphoric Monoester HydrolasesProtein Tyrosine Phosphatase, Non-Receptor Type 22PTPN22 protein, humanRNA, Small InterferingSialic Acid Binding Immunoglobulin-like Lectinsfunctionalized lipoplexesimmunotherapyPEGylated lipid F9T1Dvariant PTPN22

Identifiers

PMID35355982
PMCPMC8959661
OpenAlexW4220957988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.