Evidence map›Paper›PMID 35355927›Full record

ReviewInternational journal of cardiology. Heart & vasculature2022

Cardiovascular complications in the Post-Acute COVID-19 syndrome (PACS).

Sheref A Elseidy, Ahmed K Awad, Monica Vorla, Amina Fatima, Merihan A Elbadawy, Debvarsha Mandal, Tamam Mohamad

Open access · goldAbstract readReview
In one paragraph

Review in International journal of cardiology. Heart & vasculature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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  17. Cardiovascular disease and covid-19: A systematic review.International journal of cardiology. Heart & vasculature · 2024
    Review
  18. Recent highlights from theInternational journal of cardiology. Heart & vasculature · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Sheref A ElseidyInternal medicine department, University of Texas health sciences, Houston, TX.
Ahmed K AwadFaculty of Medicine, Ain Shams University, Cairo, Egypt.
Monica VorlaDepartment of internal medicine, University of Louisville School of Medicine, Louisville, Ky.
Amina FatimaUniversity of Louisville School of Medicine, Louisville, Ky.
Merihan A ElbadawyFaculty of Medicine, Ain Shams University, Cairo, Egypt.
Debvarsha MandalUniversity of Louisville School of Medicine, Louisville, Ky.
Tamam MohamadCardiovascular Disease Department, Wayne State University, Detroit, MI.
University of Louisville · USAin Shams University · EGThe University of Texas Health Science Center at Houston · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) or coronavirus disease 2019 (COVID-19) initially surfaced in December 2019 from Wuhan, China, sweeping the world with various strains, forcing the WHO to declare a pandemic epidemic in March 2020. Furthermore, COVID-19 manifests with a wide array of presentations from fever and fatigue to severe respiratory and cardiovascular complications. Post-COVID-19 syndrome is poorly understood affecting COVID-19 survivors at all levels of disease severity. The disease is most associated with post-discharge dyspnea and fatigue. However, other persistent symptoms as chest pains, palpitations, smell, and taste dysfunctions. Patients with high concentrations of CRP and creatinine in the acute phase of Covid-19 are more prone to cardiac sequelae. Therefore, high levels of cardiac-sensitive troponin and hypokalaemia can also be used for risk stratification. Furthermore, Cardiac damage can manifest as myocarditis, pericarditis, rhythm abnormalities. The use of different diagnostic modalities like electrocardiogram (ECG), echocardiogram, and cardiac magnetic resonance imaging (MRI)(CMR) to evaluate the myocardial damage were studied. However, Cardiovascular complications are a common manifestation of PASC, classification of severity of cardiac symptoms and the emergence of CMR as a diagnostic tool needs more evidence.

Indexed as

ACE2, Angiotensin-converting enzyme 2CAMKII, calmodulin-dependent protein kinase IICardiovascular diseasesCMR, Cardiac magnetic resonance imagingCOVID-19COVID-19, Coronavirus disease 2019CVD, Cardiovascular diseaseDAMPs, damage-associated molecular patternsIL, interleukinMyocardial infarctionNOAC, novel oral anticoagulationPACS, Post-Acute COVID-19 syndromePost covid sequelaeRAAS, Renin-Angiotensin Aldosterone System dysregulationSARS-CoV 2, severe acute respiratory syndrome coronavirus 2TMPRS2, transmembrane protease serine 2TNF-Alpha, Tumor necrosis factor-alphaTTE, transthoracic echocardiogramUFH, Unfractionated heparinVTE, venous thromboembolismWHO, World health organization

Identifiers

PMID35355927
PMCPMC8958273
OpenAlexW4220778576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.