Evidence map›Paper›PMID 35355893›Full record

ArticleOpen forum infectious diseases2022

The Incidence of Ocular Complications in Candidemic Patients and Implications for the Practice of Routine 
Eye Exams.

Molly Hillenbrand, Angelico Mendy, Kavya Patel, Racheal Wilkinson, Siyun Liao, Jamie Robertson, Senu Apewokin

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Prevalence of Ocular Candidiasis and Candida Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Epidemiology, Risk Factors and Clinical Outcome of Candidaemia:Sultan Qaboos University medical journal · 2025
    Observational
  6. Article
  7. Review
  8. Review
  9. Article
  10. Candidemia Treatment is Improved by Infectious Disease Consultation: A Population-Based Cohort Study.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Molly HillenbrandDepartment of Internal Medicine, Duke University, Durham, North Carolina, USA.
Angelico MendyDepartment of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Kavya PatelDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Racheal WilkinsonDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Siyun LiaoUniversity of Cincinnati College of Pharmacy, Cincinnati, Ohio, USA.
Jamie RobertsonDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Senu ApewokinDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0002-3915-5814
University of Cincinnati Medical Center · USDuke University · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Harnessing Induced Human Intestinal Organoids (iHIOs) and Metagenomics to Unravel Host Immune-microbiota Interactions During Cancer Chemotherapy-associated Clostridium difficile InfectionsK08CA237735 · NCI · UNIVERSITY OF CINCINNATI · PI APEWOKIN, SENU · 2020 to 2024
$1.1M
NCI NIH HHS K08 CA237735NIEHS NIH HHS P30 ES006096
6 · The paper itself

Abstract

Background: Ocular candidiasis is a known complication of candidemia. Given the poor ocular penetration of echinocandins, there is some concern that the increasing use of echinocandins may portend an increased incidence of ophthalmic complications. We examined the changing trends in antifungal prescribing patterns and the incidence of ophthalmic complications after candidemia. Methods: Patients with blood cultures positive for Results: There were 226 candidemia cases during the study period, 129 (57.1%) of which underwent screening eye exams. From 2014 to 2015, 24 of 37 (64.5%) patients received eye-penetrating antifungals compared to 36 of 92 (39.1%) from 2016 to 2020 ( Conclusions: Prescription of eye-penetrating antifungals for candidemia has trended down since 2016. This was associated with a concomitant increase in abnormal findings on screening fundoscopy. Abnormal eye exams were not uncommon throughout our study period.

Indexed as

candidemia guidelinesechinocandinsendopthalmitisocular candidiasisroutine eye-screening

Identifiers

PMID35355893
PMCPMC8962754
OpenAlexW4220726021

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.