Evidence map›Paper›PMID 35355836›Full record

ArticleACS catalysis2021

Cell-Free Total Biosynthesis of Plant Terpene Natural Products using an Orthogonal Cofactor Regeneration System.

Undramaa Bat-Erdene, John M Billingsley, William C Turner, Benjamin R Lichman, Francesca M Ippoliti, Neil K Garg, Sarah E O'Connor, Yi Tang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Undramaa Bat-ErdeneDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
John M BillingsleyDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
William C TurnerDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Benjamin R LichmanCentre for Agricultural Products, Department of Biology, University of York, Wentworth Way, York, YO10 5DD, UK.
Francesca M IppolitiDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Neil K GargDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Sarah E O'ConnorDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Hans-Knöll-Straße 8, 07745 Jena, Germany.
Yi TangDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USMax Planck Institute for Chemical Ecology · DENorthwestern University · USUniversity of York · GB

Funding

Engineering Yeast towards High Titer Production of Monoterpene Indole Alkaloid Natural ProductsR01AT010001 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Dino Di Carlo, Yi Tang · 2018 to 2026
$3.6M
NCCIH NIH HHS R01 AT010001
6 · The paper itself

Abstract

Here we report the one-pot, cell-free enzymatic synthesis of the plant monoterpene nepetalactol starting from the readily available geraniol. A pair of orthogonal cofactor regeneration systems permitted NAD

Indexed as

biocatalysiscofactor regenerationenzyme cascadenatural productssynthetic biochemistry

Identifiers

PMID35355836
PMCPMC8963176
OpenAlexW3184638853

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.