Evidence map›Paper›PMID 35355663›Full record

ArticleRespirology case reports2022

COVID-19 mRNA vaccine-related interstitial lung disease: Two case reports and literature review.

Clara So, Shinyu Izumi, Akane Ishida, Ryo Hirakawa, Yusaku Kusaba, Masao Hashimoto, Satoru Ishii, Hideki Miyazaki, Motoyasu Iikura, Masayuki Hojo

Open access · goldAbstract readCase Reports
In one paragraph

Article in Respirology case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  11. Postvaccination Acute Exacerbations of Idiopathic Pulmonary Fibrosis?American journal of respiratory and critical care medicine · 2022
    Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Clara SoDepartment of Respiratory Medicine National Center for Global Health and Medicine Shinjuku City Japan.ORCID https://orcid.org/0000-0001-7802-078X
Shinyu IzumiDepartment of Respiratory Medicine National Center for Global Health and Medicine Shinjuku City Japan.ORCID https://orcid.org/0000-0002-6384-5022
Akane IshidaDepartment of Respiratory Medicine National Center for Global Health and Medicine Shinjuku City Japan.
Ryo HirakawaDepartment of Respiratory Medicine National Center for Global Health and Medicine Shinjuku City Japan.
Yusaku KusabaDepartment of Respiratory Medicine National Center for Global Health and Medicine Shinjuku City Japan.
Masao HashimotoDepartment of Respiratory Medicine National Center for Global Health and Medicine Shinjuku City Japan.
Satoru IshiiDepartment of Respiratory Medicine National Center for Global Health and Medicine Shinjuku City Japan.ORCID https://orcid.org/0000-0002-2495-0487
Hideki MiyazakiDivision of Pathology National Center for Global Health and Medicine Shinjuku City Japan.
Motoyasu IikuraDepartment of Respiratory Medicine National Center for Global Health and Medicine Shinjuku City Japan.
Masayuki HojoDepartment of Respiratory Medicine National Center for Global Health and Medicine Shinjuku City Japan.
National Center for Global Health and Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Pfizer-BioNTech mRNA vaccine (BNT162b2) is an effective and well-tolerated coronavirus disease 2019 (COVID-19) vaccine. However, rare adverse events have been reported. We report two cases of COVID-19 mRNA vaccine-related interstitial lung disease (ILD). A 67-year-old man and a 70-year-old man with underlying ILD presented to our hospital with a few days of fever and respiratory symptoms after receiving the BNT162b2 vaccine. Drug-related pneumonitis due to the COVID-19 mRNA vaccine was diagnosed. One case was diagnosed with lymphocytic alveolitis by bronchoalveolar lavage fluid and transbronchial lung cryobiopsy. Both patients were successfully treated with corticosteroids, and they attended outpatient clinics thereafter. Although the safety and efficacy of COVID-19 vaccines have been established, further studies are needed to estimate long-term data and reports of rare adverse reactions. We present the clinical course of two cases, review previously published case reports on COVID-19 mRNA vaccine-related ILD and discuss the relevant findings.

Indexed as

COVID‐19interstitial lung diseasemRNA vaccinesteroidvaccine‐induced pneumonitis

Identifiers

PMID35355663
PMCPMC8942814
OpenAlexW4220778536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.