Evidence map›Paper›PMID 35355564›Full record

ArticleFrontiers in endocrinology2022

Identification of MAGEC2/CT10 as a High Calcium-Inducible Gene in Triple-Negative Breast Cancer.

Heather K Beasley, Sarrah E Widatalla, Diva S Whalen, Stephen D Williams, Olga Y Korolkova, Clementine Namba, Siddharth Pratap, Josiah Ochieng, Amos M Sakwe

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Gene expression regulation by CaCellular & molecular biology letters · 2026
    Pooled it
  2. Review
  3. Bugs as drugs: parasite biomolecules as novel therapeutics against breast cancer.American journal of physiology. Cell physiology · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Heather K BeasleyDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Graduate Studies and Research, Meharry Medical College, Nashville, TN, United States.
Sarrah E WidatallaDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Graduate Studies and Research, Meharry Medical College, Nashville, TN, United States.
Diva S WhalenDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Graduate Studies and Research, Meharry Medical College, Nashville, TN, United States.
Stephen D WilliamsDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Graduate Studies and Research, Meharry Medical College, Nashville, TN, United States.
Olga Y KorolkovaDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Graduate Studies and Research, Meharry Medical College, Nashville, TN, United States.
Clementine NambaDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Graduate Studies and Research, Meharry Medical College, Nashville, TN, United States.
Siddharth PratapBioinformatics Core, School of Graduate Studies and Research, Meharry Medical College, Nashville, TN, United States.
Josiah OchiengBioinformatics Core, School of Graduate Studies and Research, Meharry Medical College, Nashville, TN, United States.
Amos M SakweDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Graduate Studies and Research, Meharry Medical College, Nashville, TN, United States.
Meharry Medical College · US

Funding

TISSUE CoreP50CA098131 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PARK, BEN HO, PIETENPOL, JENNIFER A · 2003 to 2024
$48.7M
The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Maureen Sanderson · 2017 to 2026
$48.2M
Technologies and Resources CoreU54MD007593 · NIMHD · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2012 to 2018
$24.7M
THE MEHARRY RISE INITIATIVER25GM059994 · NIGMS · MEHARRY MEDICAL COLLEGE · PI MOTLEY-JOHNSON, EVANGELINE D · 1999 to 2021
$23.0M
Translational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2011 to 2025
$18.8M
Mechanisms of Annexin A6 Mediated Basal-like Breast Cancer ProgressionSC1GM139814 · NIGMS · MEHARRY MEDICAL COLLEGE · PI SAKWE, AMOS MALLE · 2021 to 2024
$1.5M
MECHANISMS OF ANNEXIN A6-MEDIATED BASAL-LIKE BREAST CANCER PROGRESSIONSC1CA211030 · NCI · MEHARRY MEDICAL COLLEGE · PI SAKWE, AMOS MALLE · 2016 to 2019
$1.5M
The role of annexin A6 in breast cancer metastasisSC2CA170244 · NCI · MEHARRY MEDICAL COLLEGE · PI SAKWE, AMOS MALLE · 2012 to 2014
$424k
NCI NIH HHS P50 CA098131NCI NIH HHS SC1 CA211030NCI NIH HHS SC2 CA170244NCI NIH HHS U54 CA163069NIGMS NIH HHS R25 GM059994NIGMS NIH HHS SC1 GM139814NIMHD NIH HHS U54 MD007586NIMHD NIH HHS U54 MD007593
6 · The paper itself

Abstract

The expression of the melanoma/cancer-testis antigen MAGEC2/CT10 is restricted to germline cells, but like most cancer-testis antigens, it is frequently upregulated in advanced breast tumors and other malignant tumors. However, the physiological cues that trigger the expression of this gene during malignancy remain unknown. Given that malignant breast cancer is often associated with skeletal metastasis and co-morbidities such as cancer-induced hypercalcemia, we evaluated the effect of high Ca

Indexed as

HypercalcemiaTriple Negative Breast NeoplasmsAntigens, NeoplasmCalciumCell Line, TumorHumansMaleNeoplasm ProteinsAntigens, NeoplasmCalciumMAGEC2 protein, humanNeoplasm ProteinsAP-1breast cancercalcium-sensing receptorcalcium signalingcell motilitycell proliferationMAGEC2TNBC

Identifiers

PMID35355564
PMCPMC8959981
OpenAlexW4220908813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.