Evidence map›Paper›PMID 35355366›Full record

ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2022

Wear and tear of the intestinal visceral musculature by intrinsic and extrinsic factors.

Ho D Kim, Eric So, Jiae Lee, Yi Wang, Vikram S Gill, Anna Gorbacheva, Hee Jin Han, Katelyn G-L Ng, Ken Ning, Inez K A Pranoto and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Ho D KimDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.
Eric SoDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.
Jiae LeeDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-5898-5728
Yi WangDepartment of Developmental and Cell Biology, School of Biological Sciences, University of California, Irvine, California, USA.
Vikram S GillDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.
Anna GorbachevaDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.
Hee Jin HanDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.
Katelyn G-L NgDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-9282-6261
Ken NingDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.
Inez K A PranotoDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-0709-5642
Alejandra J H CabreraDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-9820-2505
Dae Seok EomDepartment of Developmental and Cell Biology, School of Biological Sciences, University of California, Irvine, California, USA.ORCID 0000-0002-0617-8788
Young V KwonDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-8937-3182
University of Washington · USUniversity of California, Irvine · US

Funding

The Molecular Basis of Basal Cell Extrusion in Drosophila Intestinal EpitheliumR35GM128752 · NIGMS · UNIVERSITY OF WASHINGTON · PI Young Kwon · 2018 to 2026
$3.4M
NIGMS NIH HHS R35 GM128752
6 · The paper itself

Abstract

backgroundThe gut visceral musculature plays essential roles in not only moving substances through the lumen but also maintaining the function and physiology of the gut. Although the development of the visceral musculature has been studied in multiple model organisms, how it degenerates is poorly understood.

resultsHere, we employ the Drosophila midgut as a model to demonstrate that the visceral musculature is disrupted by intrinsic and extrinsic factors, such as aging, feeding, chemical-induced tissue damage, and oncogenic transformation in the epithelium. Notably, we define four prominent visceral musculature disruption phenotypes, which we refer as "sprout," "discontinuity," "furcation," and "crossover" of the longitudinal muscle. Given that the occurrence of these phenotypes is increased during aging and under various stresses, we propose that these phenotypes can be used as quantitative readouts of deterioration of the visceral musculature. Intriguingly, administration of a tissue-damaging chemical dextran sulfate sodium (DSS) induced similar visceral musculature disruption phenotypes in zebrafish larvae, indicating that ingestion of a tissue-damaging chemical can disrupt the visceral musculature in a vertebrate as well.

conclusionsOur study provides insights into the deterioration of the gut visceral musculature and lays a groundwork for investigating the underlying mechanisms in Drosophila as well as other animals.

Indexed as

Drosophila ProteinsZebrafishAnimalsDrosophilaEndodermMusclesDrosophila Proteinsagingdegenerationdextran sulfate sodiumDrosophilavisceral musculaturezebrafish

Identifiers

PMID35355366
PMCPMC9357160
OpenAlexW4225995936

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.