Evidence map›Paper›PMID 35355295›Full record

ArticleClinical cardiology2022

Impact of the "atherosclerotic pabulum" on in-hospital mortality for SARS-CoV-2 infection. Is calcium score able to identify at-risk patients?

Valeria Pergola, Giulio Cabrelle, Marco Previtero, Andrea Fiorencis, Giulia Lorenzoni, Carlo Maria Dellino, Carolina Montonati, Saverio Continisio, Elisa Masetto, Donato Mele and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Valeria PergolaDepartment of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0002-3317-7342
Giulio CabrelleDepartment of Medicine, Institute of Radiology, University of Padua, Padua, Italy.
Marco PreviteroDepartment of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua, Padua, Italy.
Andrea FiorencisDepartment of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua, Padua, Italy.
Giulia LorenzoniUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, Padua, Italy.
Carlo Maria DellinoDepartment of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua, Padua, Italy.
Carolina MontonatiDepartment of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua, Padua, Italy.
Saverio ContinisioDepartment of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua, Padua, Italy.
Elisa MasettoUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, Padua, Italy.
Donato MeleDepartment of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua, Padua, Italy.
Martina Perazzolo MarraDepartment of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua, Padua, Italy.
Chiara GiraudoDepartment of Medicine, Institute of Radiology, University of Padua, Padua, Italy.
Giulio BarbieroRadiology Unit, Padova University Hospital, Padua, Italy.
Giorgio De ContiRadiology Unit, Padova University Hospital, Padua, Italy.
Giovanni Di SalvoDepartment of Women's and Children's Health, University of Padua, Padua, Italy.
Dario GregoriUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, Padua, Italy.
Sabino IlicetoDepartment of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua, Padua, Italy.
Raffaella MottaUnit of Advanced and Translational Diagnostics, Department of Medicine, University of Padua, Padua, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough the primary cause of death in COVID-19 infection is respiratory failure, there is evidence that cardiac manifestations may contribute to overall mortality and can even be the primary cause of death. More importantly, it is recognized that COVID-19 is associated with a high incidence of thrombotic complications. HYPOTHESIS: Evaluate if the coronary artery calcium (CAC) score was useful to predict in-hospital (in-H) mortality in patients with COVID-19. Secondary end-points were needed for mechanical ventilation and intensive care unit admission.

methodsTwo-hundred eighty-four patients (63, 25 years, 67% male) with proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who had a noncontrast chest computed tomography were analyzed for CAC score. Clinical and radiological data were retrieved.

resultsPatients with CAC had a higher inflammatory burden at admission (d-dimer, p = .002; C-reactive protein, p = .002; procalcitonin, p = .016) and a higher high-sensitive cardiac troponin I (HScTnI, p = <.001) at admission and at peak. While there was no association with presence of lung consolidation and ground-glass opacities, patients with CAC had higher incidence of bilateral infiltration (p = .043) and higher in-H mortality (p = .048). On the other side, peak HScTnI >200 ng/dl was a better determinant of all outcomes in both univariate (p = <.001) and multivariate analysis (p = <.001).

conclusionThe main finding of our research is that CAC was positively related to in-H mortality, but it did not completely identify all the population at risk of events in the setting of COVID-19 patients. This raises the possibility that other factors, including the presence of soft, unstable plaques, may have a role in adverse outcomes in SARS-CoV-2 infection.

Indexed as

COVID-19CalciumFemaleHospital MortalityHumansMaleRespiration, ArtificialSARS-CoV-2Calciumcardiovascular riskchest computed tomographycoronary calcium scoreSARS-CoV-2 infection

Identifiers

PMID35355295
PMCPMC9110910
OpenAlexW4220696752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.