Evidence map›Paper›PMID 35355219›Full record

ArticleCerebellum (London, England)2023

Cerebellar Transcranial Magnetic Stimulation (TMS) Impairs Visual Working Memory.

Nestor Viñas-Guasch, Tommy Hock Beng Ng, Jiamin Gladys Heng, Yee Cheun Chan, Effie Chew, John E Desmond, S H Annabel Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebellum (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Microstructural Alterations of the Cerebellum-Ventral Tegmental Area Pathways in First-Episode Psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Article
  3. An update on the effects of cerebellar transcranial magnetic stimulation on cognitive function.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nestor Viñas-GuaschPsychology, School of Social Sciences, Nanyang Technological University, Singapore, Singapore.
Tommy Hock Beng NgNational Institute of Education, Nanyang Technological University, Singapore, Singapore.
Jiamin Gladys HengPsychology, School of Social Sciences, Nanyang Technological University, Singapore, Singapore.
Yee Cheun ChanDivision of Neurology, University Medicine Cluster, National University Health System, Singapore, Singapore.
Effie ChewDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
John E DesmondThe Johns Hopkins University School of Medicine, Baltimore, USA.
S H Annabel ChenPsychology, School of Social Sciences, Nanyang Technological University, Singapore, Singapore. annabelchen@ntu.edu.sg.ORCID http://orcid.org/0000-0002-1540-5516

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
Investigation of Cerebellar Involvement in Cognitive FunctionR01MH104588 · NIMH · JOHNS HOPKINS UNIVERSITY · PI DESMOND, JOHN E · 2015 to 2020
$2.7M
NICHD NIH HHS P50 HD103538NIMH NIH HHS R01 MH104588
6 · The paper itself

Abstract

An increasing body of evidence points to the involvement of the cerebellum in cognition. Specifically, previous studies have shown that the superior and inferior portions of the cerebellum are involved in different verbal working memory (WM) mechanisms as part of two separate cerebro-cerebellar loops for articulatory rehearsal and phonological storage mechanisms. In comparison, our understanding of the involvement of the cerebellum in visual WM remains limited. We have previously shown that performance in verbal WM is disrupted by single-pulse transcranial magnetic stimulation (TMS) of the right superior cerebellum. The present study aimed to expand on this notion by exploring whether the inferior cerebellum is similarly involved in visual WM. Here, we used fMRI-guided, double-pulse TMS to probe the necessity of left superior and left inferior cerebellum in visual WM. We first conducted an fMRI localizer using the Sternberg visual WM task, which yielded targets in left superior and inferior cerebellum. Subsequently, TMS stimulation of these regions at the end of the encoding phase resulted in decreased accuracy in the visual WM task. Differences in the visual WM deficits caused by stimulation of superior and inferior left cerebellum raise the possibility that these regions are involved in different stages of visual WM.

Indexed as

Memory, Short-TermTranscranial Magnetic StimulationCerebellumCognitionMagnetic Resonance ImagingCerebellumNeuro-navigationPhonological loopVisual attentionVisual working memory

Identifiers

PMID35355219
PMCPMC9522915

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.