Evidence map›Paper›PMID 35355216›Full record

ArticleNeurocritical care2022

Effect of Obstructive Sleep Apnea on Outcomes After Traumatic Brain Injury: A Retrospective Cohort Analysis.

Talha Mubashir, Hunza S Ahmad, Hongyin Lai, Rabail Chaudhry, Vahed Maroufy, Julius Balogh, Biai Dominique, Ray Hwong, Frances Chung, George W Williams

Abstract read
PubMed Publisher
In one paragraph

Article in Neurocritical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Talha MubashirDepartment of Anesthesiology, Division of Critical Care Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Hunza S AhmadDepartment of Anesthesiology, Division of Critical Care Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Hongyin LaiDepartment of Biostatistics, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Rabail ChaudhryDepartment of Anesthesiology and Pain Medicine, University of Toronto and University Health Network, Toronto, Canada.
Vahed MaroufyDepartment of Biostatistics, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Julius BaloghDepartment of Anesthesiology and Critical Care, University of Arkansas Medical Center, Little Rock, AR, USA.
Biai DominiqueDepartment of Anesthesiology, Division of Critical Care Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Ray HwongDepartment of Anesthesiology, Division of Critical Care Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Frances ChungDepartment of Anesthesiology and Pain Medicine, University of Toronto and University Health Network, Toronto, Canada.
George W WilliamsDepartment of Anesthesiology, Division of Critical Care Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. George.W.Williams@uth.tmc.edu.ORCID http://orcid.org/0000-0001-9079-610X
The University of Texas Health Science Center at Houston · USUniversity Health Network · CAThe University of Texas Health Science Center · USUniversity of Arkansas Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraumatic brain injury (TBI) and obstructive sleep apnea (OSA) are common in the general population and are associated with significant morbidity and mortality. The objective of this study was to assess hospital outcomes of patients with TBI with and without a pre-existing OSA diagnosis.

methodsWe retrospectively analyzed data from the National Inpatient Sample (NIS) database of adult patients aged ≥ 18 years with a primary diagnosis of TBI. In-hospital outcomes were assessed among patients with TBI with and without pre-existing OSA hospitalized between 2005 to 2015 in the United States. Propensity score matching and conditional logistic regression models were used to analyze in-hospital mortality, length of hospitalization, and in-hospital complications among patients with TBI with and without a pretrauma OSA diagnosis.

resultsIn our TBI cohort, the overall prevalence of diagnosed OSA was 0.90%. Patients with OSA were mostly obese or morbidly obese older men with high comorbidity burden and sustained more severe head injuries yet were less likely to undergo craniotomy or craniectomy. Following propensity score matching, the odds risk (OR) of in-hospital mortality was significantly lower in the OSA group with TBI (OR 0.58; p < 0.001). Compared with the non-OSA group, patients with OSA had significantly higher risk of respiratory complications (OR 1.23) and acute heart failure (OR 1.25) and lower risk of acute myocardial infarction (OR 0.73), cardiogenic shock (OR 0.34), and packed red blood cell transfusions (OR 0.79). Patients with OSA spent on average 0.3 days less (7.4 vs. 7.7 days) hospitalized compared with the non-OSA group.

conclusionsPatients with TBI with underlying OSA diagnosis were older and had higher comorbidity burden; however, hospital mortality was lower. Pre-existing OSA may result in protective physiologic changes such as hypoxic-ischemic preconditioning especially to cardiac and neural tissues, which can provide protection following neurological trauma, which may lead to a reduction in mortality.

Indexed as

Brain Injuries, TraumaticObesity, MorbidSleep Apnea, ObstructiveAdultAgedCohort StudiesComorbidityHumansLength of StayLogistic ModelsMaleRetrospective StudiesRisk FactorsUnited StatesAdultsObstructive sleep apneaTraumatic brain injury

Identifiers

PMID35355216
OpenAlexW4220676113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.