ArticleApplied microbiology and biotechnology2022
Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger.
Article in Applied microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- New insights into the roles of fungi and bacteria in the development of medicinal plant.Journal of advanced research · 2024Review
- Review
- Antimalarial Mechanisms and Resistance Status of Artemisinin and Its Derivatives.Tropical medicine and infectious disease · 2024Review
- Fungal-Mediated Biotransformation of the Plant Growth Regulator Forchlorfenuron byMetabolites · 2024Article
- Biotransformation of Ursonic Acid byMolecules (Basel, Switzerland) · 2023Article
- In vitro and in vivo antimalarial activity and chemical profiling of sugarcane leaves.Scientific reports · 2022Article
- Combined chemical transformation and biological transformation of artemisinin: A facile approach to diverse artemisinin derivatives.Frontiers in chemistry · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artemisinin is a component part of current frontline medicines for the treatment of malaria. The aim of this study is to make analogues of artemisinin using microbial transformation and evaluate their in vitro antimalarial activity. A panel of microorganisms were screened for biotransformation of artemisinin (1). The biotransformation products were extracted, purified and isolated using silica gel column chromatography and semi-preparative HPLC. Spectroscopic methods including LC-HRMS, GC-MS, FT-IR, 1D and 2D NMR were used to elucidate the structure of the artemisinin metabolites.
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Registered trials
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