ArticleNature2022
Obesity alters pathology and treatment response in inflammatory disease.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 1 pooled it
19.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 1 synthesis or guideline pooled it, 239 citations in OpenAlex.
- Gastric cancer after Bariatric Bypass Surgery. Do they relate? (A Systematic Review).Obesity surgery · 2023Pooled it
- From Inclusion Complexes to Metabolic Signaling: The Emerging Role of γ-Cyclodextrin in Gut Microbiota and Metabolic Regulation.Molecules (Basel, Switzerland) · 2026Review
- Obesity, Inflammation, and Tumor Microenvironment in Three-Dimensional Models of Breast Cancer.Cells · 2026Review
- Phenotypic characterization of treatment-naïve childhood asthma with obesity: features of lung function, inflammation, and lipid profiles.European journal of pediatrics · 2026Article
- PPAR-γ suppresses macrophage senescence and allergic airway inflammation through controlling lipid metabolic pathways.EBioMedicine · 2026Article
- Overweight, obesity, adiposity measures, and asthma endotypes in Puerto Rican youth.American journal of respiratory and critical care medicine · 2026Article
- Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis.Nature communications · 2026Article
- Lysophosphatidylcholine 18:2 exacerbates Th17-dominant inflammation in obese asthma.Lipids in health and disease · 2026Article
- Lipid metabolism in homeostasis and disease.Signal transduction and targeted therapy · 2026Review
- Article
- Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity.Science (New York, N.Y.) · 2026Article
- Multidimensional Analysis of Serum Adiponectin, Leptin, and Resistin Levels and Their Correlation with Childhood Obesity Based on Gut Microbiota and Inflammatory Markers: A Single-Center Cross-Sectional Retrospective Study.International journal of general medicine · 2026Article
- Combination of Chenpi and Banxia alleviates synovial inflammation in a rat model of rheumatoid arthritis by targeting the JNK/AP-1 signaling pathway.Frontiers in immunology · 2026Article
- Unveiling the pathways of Xuanbai Chengqi Decoction in obese asthma: from immune modulation to microbial restoration.Frontiers in nutrition · 2026Article
- PPARγ: a key orchestrator of epidermal barrier, immune responses, and lipid metabolism in atopic dermatitis pathogenesis and therapy.Frontiers in allergy · 2026Review
- High Fat Diet-Induced Obesity Alters Cutaneous Immune Cell Function, and These Changes Persist After Weight Loss.Journal of immunology research · 2026Article
- Real-world effectiveness of biologic therapies in severe asthma patients ineligible for phase 3 randomised controlled trials of biologics: an analysis from the UK Severe Asthma Registry.ERJ open research · 2026Article
- Is higher body mass index correlated with worse clinical outcomes in acute liver failure?World journal of clinical cases · 2025Article
- High prevalence and distinct patterns of metabolic syndrome in rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis: a population-based study.Rheumatology international · 2025Article
- Association between multifactorial control and excess risk of liver diseases in type 2 diabetes: a prospective cohort study.BMJ open diabetes research & care · 2025Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
43 authors at 11 institutions in 4 countries.
Sagar P BapatNOMIS Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA, USA. sagar.bapat@ucsf.edu.ORCID http://orcid.org/0000-0002-4402-1511
Caroline Whitty *Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Cody T Mowery *Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Yuqiong Liang *NOMIS Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Arum YooDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Zewen JiangDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3852-8666
Michael C PetersDivision of Pulmonary, Critical Care, Allergy and Sleep, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Ling-Juan ZhangSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, China.ORCID http://orcid.org/0000-0001-6937-4578
Ian VogelDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Carmen ZhouNOMIS Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Vinh Q NguyenDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Zhongmei LiDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Christina ChangNOMIS Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Wandi S ZhuDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Annette T HastieSchool of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Helen HeDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Xin RenLung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Wenli QiuLung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Sarah G GayerDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1032-5971
Chang LiuDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Eun Jung ChoiDepartment of Biomedical Science, Graduate School, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Marlys FassettDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5750-1928
Jarish N CohenDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.
Jamie L SturgillDepartment of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY, USA.
Laura E Crotty AlexanderPulmonary Critical Care Section, Department of Medicine, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-5091-2660
Jae Myoung SuhGraduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea.
Christopher LiddleStorr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia.ORCID http://orcid.org/0000-0003-3936-6790
Annette R AtkinsGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Ruth T YuGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9527-9627
Michael DownesGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Sihao LiuGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Barbara S NikolajczykDepartment of Pharmacology and Nutritional Sciences and the Barnstable Brown Diabetes and Obesity Research Center, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0001-5647-5740
In-Kyu LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.ORCID http://orcid.org/0000-0002-1655-0985
Emma Guttman-YasskyDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-9363-324X
K Mark AnselDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-4840-9879
Prescott G WoodruffMedical Scientist Training Program, University of California, San Francisco, CA, USA.
John V FahyMedical Scientist Training Program, University of California, San Francisco, CA, USA.
Dean SheppardMedical Scientist Training Program, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6277-2036
Richard L GalloSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, China.ORCID http://orcid.org/0000-0002-1401-7861
Chun Jimmie YeInstitute for Human Genetics (IHG), University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6560-3783
Ronald M EvansGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA. evans@salk.edu.ORCID http://orcid.org/0000-0002-9986-5965
Ye ZhengNOMIS Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA, USA. yzheng@salk.edu.ORCID http://orcid.org/0000-0001-5012-4309
Alexander MarsonDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.ORCID http://orcid.org/0000-0002-2734-5776
University of California, San Francisco · USSalk Institute for Biological Studies · USIcahn School of Medicine at Mount Sinai · USKyungpook National University Hospital · KRUniversity of Kentucky · USXiamen University · CNGladstone Institutes · USKorea Advanced Institute of Science and Technology · KRThe University of Sydney · AUUniversity of California System · USWake Forest University · US
Funding
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8MYeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MRole of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8MThe role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2012 to 2017
$13.7MTissue-specific roles of FXR in CVD and NASHP01HL147835 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EVANS, RONALD M · 2020 to 2024
$12.2MProtein carbohydrate interactions in the pathophysiology of asthma exacerbationsR01HL080414 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John V Fahy · 2005 to 2026
$9.2MPilot Projects ProgramP30GM127211 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2018 to 2022
$5.7MRole of miRNAs in Th2-Driven inflammation in AsthmaR01HL109102 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Karl Mark Ansel · 2011 to 2026
$5.5MAmerican Heart Association-American Stroke Association 16BGIA27790079BLRD VA IK2 BX001313NCI NIH HHS P30 CA014195NHLBI NIH HHS K38 HL154202NHLBI NIH HHS P01 HL107202NHLBI NIH HHS P01 HL147835NHLBI NIH HHS R01 HL080414NHLBI NIH HHS R01 HL105278NHLBI NIH HHS R01 HL109102NHLBI NIH HHS R38 HL143581NIAID NIH HHS R01 AI107027NIAID NIH HHS R01 AI151123NIAID NIH HHS R01 AI153185NIAID NIH HHS R21 AI154919NIAID NIH HHS R37 AI052453NIAMS NIH HHS R01 AR076082NIDDK NIH HHS F30 DK096828NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK063720NIDDK NIH HHS R01 DK057978NIDDK NIH HHS R01 DK120480NIEHS NIH HHS P42 ES010337NIGMS NIH HHS P20 GM103527NIGMS NIH HHS P30 GM127211NIGMS NIH HHS T32 GM007198NIH HHS R01 DK121760NIH HHS S10 OD023689NIH HHS U01 AI52038Wellcome Trust
Abstract
Decades of work have elucidated cytokine signalling and transcriptional pathways that control T cell differentiation and have led the way to targeted biologic therapies that are effective in a range of autoimmune, allergic and inflammatory diseases. Recent evidence indicates that obesity and metabolic disease can also influence the immune system
Indexed as
Dermatitis, AtopicPPAR gammaAnimalsCytokinesDisease Models, AnimalInflammationMiceObesityPrecision MedicineSequence Analysis, RNATh2 CellsCytokinesPPAR gamma
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.