Evidence map›Paper›PMID 35355020›Full record

ArticleNature2022

Differential assembly diversifies GABA

Andrija Sente, Rooma Desai, Katerina Naydenova, Tomas Malinauskas, Youssef Jounaidi, Jonas Miehling, Xiaojuan Zhou, Simonas Masiulis, Steven W Hardwick, Dimitri Y Chirgadze and 2 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Cys-loop receptors on cannabinoids: All high?Frontiers in physiology · 2022
    Pooled it
  2. Protein-Ratio Rheostats: Integrating Stoichiometry, Abundance, and Binding Affinity in Cellular Function.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  3. Review
  4. GABASynapse (New York, N.Y.) · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Activation of the human β3 GABABiochemical pharmacology · 2026
    Article
  11. Article
  12. The human GABAbioRxiv : the preprint server for biology · 2026
    Article
  13. Molecular assemblies and pharmacology of cerebellar GABAProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Article
  15. The human GABAmicroPublication biology · 2026
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. The Somatostatin Pathway Projected from the Basal Forebrain to the Lateral Habenula Promotes Isoflurane Anesthesia Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Andrija SenteMRC Laboratory of Molecular Biology, Cambridge, UK. asente@mrc-lmb.cam.ac.uk.
Rooma DesaiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Katerina NaydenovaMRC Laboratory of Molecular Biology, Cambridge, UK.
Tomas MalinauskasDivision of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4847-5529
Youssef JounaidiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jonas MiehlingMRC Laboratory of Molecular Biology, Cambridge, UK.
Xiaojuan ZhouDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Simonas MasiulisMRC Laboratory of Molecular Biology, Cambridge, UK.
Steven W HardwickDepartment of Biochemistry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9246-1864
Dimitri Y ChirgadzeDepartment of Biochemistry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9942-0993
Keith W MillerDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. k_miller@helix.mgh.harvard.edu.ORCID http://orcid.org/0000-0002-4105-6639
A Radu AricescuMRC Laboratory of Molecular Biology, Cambridge, UK. radu@mrc-lmb.cam.ac.uk.ORCID http://orcid.org/0000-0003-3783-1388
MRC Laboratory of Molecular Biology · GBHarvard University · USUniversity of Cambridge · GBCentre for Human Genetics · GB

Funding

Synthetic Chemistry CoreP01GM058448 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KEITH W · 1999 to 2018
$33.6M
Molecular Pharmacology of the Synaptic and Extrasynaptic GABA(A) ReceptorsR01GM135550 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KEITH W · 2020 to 2023
$2.8M
Medical Research Council MC_EX_MR/L009609/2Medical Research Council MC_EX_MR/T046279/1Medical Research Council MC_UP_1201/15Medical Research Council MR/L009609/1NIGMS NIH HHS P01 GM058448NIGMS NIH HHS R01 GM135550Wellcome Trust 202905/Z/16/ZWellcome Trust 206171/Z/17/Z
6 · The paper itself

Abstract

Type A γ-aminobutyric acid receptors (GABA

Indexed as

BenzodiazepinesReceptors, GABA-ASignal TransductionBinding SitesCryoelectron Microscopygamma-Aminobutyric AcidHistamineHumansLigandsProtein SubunitsRNA-SeqSingle-Cell AnalysisBenzodiazepinesgamma-Aminobutyric AcidHistamineLigandsProtein SubunitsReceptors, GABA-A

Identifiers

PMID35355020
PMCPMC7612593
OpenAlexW4220692518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.