ArticleNature2022
N
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 79 citations in OpenAlex.
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- Characterization of METTL3/14-mediated m6A modification in human transcriptome using Nanopore direct RNA sequencing.PLoS genetics · 2026Article
- PAPOLA-mediated hyperactive polyadenylation promotes leukemogenesis and leukemia stem cell self-renewal through metabolic reprogramming.Nature cancer · 2026Article
- Endoplasmic reticulum engagement of transcripts triggers VSG mRNA balancing in trypanosomes.PLoS pathogens · 2026Article
- Specialized RNA decay fine-tunes monogenic antigen expression in Trypanosoma brucei.Nature microbiology · 2026Article
- m6A-Modified Nucleotide Bases Improve Translation of In Vitro-Transcribed Chimeric Antigen Receptor (CAR) mRNA in T Cells.International journal of molecular sciences · 2026Article
- M6AREG 2.0: the landscape of m6A-centered crosstalk with diverse epigenetic regulation.Nucleic acids research · 2026Article
- The Dual Role of the 16mer Motif Within the 3' Untranslated Region of the Variant Surface Glycoprotein of Trypanosoma brucei.Molecular microbiology · 2026Article
- NResearch (Washington, D.C.) · 2026Article
- Nanopore-mFrontiers in genetics · 2026Article
- mRNA based vaccines and therapeutics for parasitic infections: a comprehensive review.Journal of nanobiotechnology · 2025Review
- Poly(A) tail regulation in stem cells and early development.Cell regeneration (London, England) · 2025Review
- A non-coding role for trypanosome VSG transcripts in allelic exclusion.Nucleic acids research · 2025Article
- RNA modification is the mark and strategy for host-microbe interactions.Cellular and molecular life sciences : CMLS · 2025Review
- Impact on the Leishmania mexicana transcriptome due to knockout of genes encoding orthologs of methyltransferases involved in m1A and m5C mRNA modifications.Parasites & vectors · 2025Article
- Quantitative modeling of mRNA degradation reveals tempo-dependent mRNA clearance in early embryos.Nucleic acids research · 2025Article
- The m6A demethylase FTO regulates TNF-α expression in human macrophages following Toxoplasma gondii infection.PLoS neglected tropical diseases · 2025Article
- m6A modification is incorporated into bacterial mRNA without specific functional benefit.Nucleic acids research · 2025Article
- Mechanism of N6-Methyladenosine Modification in the Pathogenesis of Depression.Molecular neurobiology · 2025Review
- Research progress of mosquito-borne virus mRNA vaccines.Molecular therapy. Methods & clinical development · 2025Review
Corrections and comments
- Commented on byPoly(m2022
Authors and funding
12 authors at 3 institutions in 4 countries.
Idálio J ViegasInstituto de Medicina Molecular-João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Juan Pereira de Macedo *Instituto de Medicina Molecular-João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Lúcia Serra *Instituto de Medicina Molecular-João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Mariana De NizInstituto de Medicina Molecular-João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.ORCID http://orcid.org/0000-0001-6987-6789
Adriana TemporãoInstituto de Medicina Molecular-João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-1208-9984
Sara Silva PereiraInstituto de Medicina Molecular-João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Aashiq H MirzaDepartment of Pharmacology, Weill Medical College, Cornell University, New York, NY, USA.
Ed BergstromDepartment of Chemistry, University of York, York, UK.
João A RodriguesInstituto de Medicina Molecular-João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Francisco Aresta-BrancoInstituto de Medicina Molecular-João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Samie R JaffreyDepartment of Pharmacology, Weill Medical College, Cornell University, New York, NY, USA.ORCID http://orcid.org/0000-0003-3615-6958
Luisa M FigueiredoInstituto de Medicina Molecular-João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. lmf@medicina.ulisboa.pt.ORCID http://orcid.org/0000-0002-5752-6586
University of Lisbon · PTCornell University · USUniversity of York · GB
Funding
CANCER PHARMACOLOGYT32CA062948 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORRAINE J GUDAS · 1994 to 2026
$12.1MNew mechanisms and technologies for understanding post-transcriptional gene regulation in neuronsR35NS111631 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAMIE R JAFFREY · 2019 to 2026
$8.6MNCI NIH HHS T32 CA062948NINDS NIH HHS R35 NS111631
Abstract
RNA modifications are important regulators of gene expression
Indexed as
RNA Processing, Post-TranscriptionalTrypanosoma brucei bruceiVariant Surface Glycoproteins, Trypanosoma3' Untranslated RegionsAdenosineGene Expression RegulationRNARNA, MessengerTranscription, Genetic3' Untranslated RegionsAdenosineN-methyladenosineRNARNA, MessengerVariant Surface Glycoproteins, Trypanosoma
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.