Evidence map›Paper›PMID 35355014›Full record

ArticleNature2022

Rixosomal RNA degradation contributes to silencing of Polycomb target genes.

Haining Zhou, Chad B Stein, Tiasha A Shafiq, Gergana Shipkovenska, Marian Kalocsay, Joao A Paulo, Jiuchun Zhang, Zhenhua Luo, Steven P Gygi, Karen Adelman and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Haining ZhouHoward Hughes Medical Institute, Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Chad B SteinDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4711-3611
Tiasha A ShafiqHoward Hughes Medical Institute, Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Gergana ShipkovenskaHoward Hughes Medical Institute, Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Marian KalocsayDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4187-5829
Joao A PauloDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4291-413X
Jiuchun ZhangInitiative for Genome Editing and Neurodegeneration, Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Zhenhua LuoPrecision Medicine Institute, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Steven P GygiDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7626-0034
Karen AdelmanDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5364-334X
Danesh MoazedHoward Hughes Medical Institute, Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. danesh@hms.harvard.edu.ORCID http://orcid.org/0000-0003-0321-6221
Harvard University · USHoward Hughes Medical Institute · USSun Yat-sen University · CN

Funding

RNAi-mediated Targeting of Hetorochromatin AssemblyR01GM072805 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MOAZED, DANESH · 2005 to 2025
$6.9M
Probing the specificity and activity of the metazoan Integrator complexR01GM134539 · NIGMS · HARVARD MEDICAL SCHOOL · PI Karen L Adelman, ERIC J WAGNER · 2019 to 2026
$4.7M
Advancing Multiplexed Isobaric Tag-based Strategies for Proteome ProfilingR01GM132129 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2019 to 2023
$1.7M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM072805NIGMS NIH HHS R01 GM132129NIGMS NIH HHS R01 GM134539
6 · The paper itself

Abstract

Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) are histone-modifying and -binding complexes that mediate the formation of facultative heterochromatin and are required for silencing of developmental genes and maintenance of cell fate

Indexed as

Gene SilencingHeterochromatinPolycomb Repressive Complex 1RNA StabilityExoribonucleasesHumansPolycomb-Group ProteinsPolycomb Repressive Complex 2SchizosaccharomycesExoribonucleasesHeterochromatinPolycomb-Group ProteinsPolycomb Repressive Complex 1Polycomb Repressive Complex 2XRN2 protein, human

Identifiers

PMID35355014
PMCPMC8986528
OpenAlexW4221097859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.