Evidence map›Paper›PMID 35355011›Full record

ArticleNature2022

Targeting Xist with compounds that disrupt RNA structure and X inactivation.

Rodrigo Aguilar, Kerrie B Spencer, Barry Kesner, Noreen F Rizvi, Maulik D Badmalia, Tyler Mrozowich, Jonathan D Mortison, Carlos Rivera, Graham F Smith, Julja Burchard and 4 more

Abstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Human lncRNAProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. International journal of molecular sciences · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Structural basis for the function of long noncoding RNAbioRxiv : the preprint server for biology · 2025
    Article
  17. Review
  18. Article
  19. Review
  20. Review

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Rodrigo AguilarDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0410-5478
Kerrie B SpencerMerck & Co., Boston, MA, USA.
Barry KesnerDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Noreen F RizviMerck & Co., Boston, MA, USA.
Maulik D BadmaliaAlberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, Alberta, Canada.
Tyler MrozowichAlberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, Alberta, Canada.
Jonathan D MortisonMerck & Co., Boston, MA, USA.
Carlos RiveraDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Graham F SmithMerck & Co., Boston, MA, USA.
Julja BurchardMerck & Co., Boston, MA, USA.
Peter J DandlikerMerck & Co., Boston, MA, USA.
Trushar R PatelAlberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, Alberta, Canada.ORCID http://orcid.org/0000-0003-0627-2923
Elliott B NickbargMerck & Co., Boston, MA, USA.
Jeannie T LeeDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. lee@molbio.mgh.harvard.edu.ORCID http://orcid.org/0000-0001-7786-8850

Funding

Investigating a candidate therapeutic for Rett SyndromeR01MH118351 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI JEANNIE T LEE · 2019 to 2026
$6.2M
Spreading of Xist RNA and Polycomb complexes along the inactive X-chromosome.R01HD097665 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, JEANNIE T · 2019 to 2023
$3.5M
Howard Hughes Medical InstituteNICHD NIH HHS R01 HD097665NIMH NIH HHS R01 MH118351Wellcome Trust
6 · The paper itself

Abstract

Although more than 98% of the human genome is non-coding

Indexed as

Chromosomes, Human, XRNA, Long NoncodingX Chromosome InactivationCell DifferentiationFemaleHistonesHumansHistonesRNA, Long NoncodingXIST non-coding RNA

Identifiers

PMID35355011
PMCPMC11549687

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.