Evidence map›Paper›PMID 35355008›Full record

ArticleNature2022

Crucial role and mechanism of transcription-coupled DNA repair in bacteria.

Binod K Bharati, Manjunath Gowder, Fangfang Zheng, Khaled Alzoubi, Vladimir Svetlov, Venu Kamarthapu, Jacob W Weaver, Vitaly Epshtein, Nikita Vasilyev, Liqiang Shen and 2 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. RfaH licenses RNA polymerase for long-range transcription.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Binod K Bharati *Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Manjunath Gowder *Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Fangfang ZhengKey Laboratory of Synthetic Biology, Chinese Academy of Sciences Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Khaled AlzoubiDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Vladimir SvetlovDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Venu KamarthapuDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Jacob W WeaverDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Vitaly EpshteinDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Nikita VasilyevDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-9918-5735
Liqiang ShenKey Laboratory of Synthetic Biology, Chinese Academy of Sciences Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Yu ZhangKey Laboratory of Synthetic Biology, Chinese Academy of Sciences Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China. yzhang@cemps.ac.cn.ORCID http://orcid.org/0000-0002-1778-8389
Evgeny NudlerDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA. evgeny.nudler@nyulangone.org.ORCID http://orcid.org/0000-0002-8811-3071
New York University · USHoward Hughes Medical Institute · USChinese Academy of Sciences · CN

Funding

Transcription termination and gene regulation by Rho: Integrative analysisR01GM126891 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NUDLER, EVGENY A · 2018 to 2021
$2.3M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM126891
6 · The paper itself

Abstract

Transcription-coupled DNA repair (TCR) is presumed to be a minor sub-pathway of nucleotide excision repair (NER) in bacteria. Global genomic repair is thought to perform the bulk of repair independently of transcription. TCR is also believed to be mediated exclusively by Mfd-a DNA translocase of a marginal NER phenotype

Indexed as

Bacterial ProteinsDNA RepairEscherichia coliTranscription, GeneticAdenosine TriphosphatasesBacteriaDNA-Binding ProteinsDNA DamageDNA-Directed RNA PolymerasesDNA HelicasesEscherichia coli ProteinsAdenosine TriphosphatasesBacterial ProteinsDNA-Binding ProteinsDNA-Directed RNA PolymerasesDNA HelicasesEscherichia coli ProteinsUvrA protein, E coliUvrB protein, E coliUvrD protein, E coli

Identifiers

PMID35355008
PMCPMC9370829
OpenAlexW4221041878

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.