Evidence map›Paper›PMID 35354951›Full record

ArticleNature immunology2022

The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα

Jia Nie, Andrea C Carpenter, Laura B Chopp, Ting Chen, Mariah Balmaceno-Criss, Thomas Ciucci, Qi Xiao, Michael C Kelly, Dorian B McGavern, Yasmine Belkaid and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. GPR15-guided CD8Nature · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Intraepithelial Lymphocytes of the Intestine.Annual review of immunology · 2024
    Review
  11. Review
  12. Article
  13. A body map of super-enhancers and their function in pig.Frontiers in veterinary science · 2023
    Article
  14. Development and function of natural TCRFrontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Jia NieLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.
Andrea C Carpenter *Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-4268-4853
Laura B Chopp *Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6494-4439
Ting ChenLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.
Mariah Balmaceno-CrissLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5065-6062
Thomas CiucciLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5828-0207
Qi XiaoLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.
Michael C KellyCCR Single Analysis Facility, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA.
Dorian B McGavernViral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9568-545X
Yasmine BelkaidMetaorganism Immunology Section, Laboratory of Immune System Biology, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9962-3571
Rémy BosselutLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA. bosselur@nih.gov.ORCID http://orcid.org/0000-0003-2033-1790
National Institutes of Health · USFrederick National Laboratory for Cancer Research · USNational Institute of Allergy and Infectious Diseases · USNational Institute of Neurological Disorders and Stroke · US

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Genetic Analysis of T-cell DifferentiationZIABC010671 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BOSSELUT, REMY · 2009 to 2025
$34.3M
Pathogenesis of viral meningitisZIANS003112 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.6M
NIAID Microbiome ProgramZICAI001233 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MOUTSOPOULOS, NIKI · 2018 to 2025
$18.9M
Single Cell Analysis FacilityZICBC012123 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KELLY, MICHAEL · 2022 to 2025
$7.3M
Role of Tissue-Specific Factors in the Control of ImmunityZIAAI001132 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BELKAID, YASMINE · 2011 to 2025
$6.4M
Intramural NIH HHS Z99 CA999999NCI NIH HHS 75N91019D00024
6 · The paper itself

Abstract

While T cell receptor (TCR) αβ

Indexed as

Intraepithelial LymphocytesLeukemiaLymphomaAnimalsCD8 AntigensCD8-Positive T-LymphocytesIntegrin beta ChainsIntestinal MucosaMiceMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaTranscription FactorsCD8 Antigensintegrin beta7Integrin beta ChainsReceptors, Antigen, T-Cell, alpha-betaTranscription Factors

Identifiers

PMID35354951
PMCPMC9290758
OpenAlexW4221059234

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.