ArticleEuropean journal of clinical nutrition2022
Association among prognostic nutritional index, post-operative infection and prognosis of stage II/III gastric cancer patients following radical gastrectomy.
Article in European journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Prognostic nutritional index (PNI) is a predictor of adverse outcomes following open ventral hernia repair.Surgical endoscopy · 2026Article
- Integrated Prognostic Stratification After Perioperative FLOT in Gastric and Gastroesophageal Junction Adenocarcinoma: A Multicenter Real-World Study.Journal of clinical medicine · 2026Article
- Dynamic machine learning model integrating resting energy expenditure for predicting postoperative complications after gastrectomy for gastric cancer.Journal of cancer research and clinical oncology · 2026Article
- A nutrition-focused model for predicting postoperative complications in locally advanced gastric cancer after neoadjuvant chemotherapy: a retrospective cohort study.BMC gastroenterology · 2026Article
- Observational
- Validation of the predictive value of combined prealbumin and lymphocyte score for prognosis of stage II/III gastric cancer following curative resection.Frontiers in oncology · 2026Article
- Association of preoperative prognostic nutritional index with postoperative delirium after gastric cancer surgery.Frontiers in nutrition · 2026Article
- Article
- Predictive role of a novel nutrition and inflammation-based model in the short-term clinical outcomes and health-related quality of life of patients undergoing radical gastrectomy: a retrospective cohort study.Discover oncology · 2025Article
- Modified RECIST submodels and ordinal regression model predict neoadjuvant chemoimmunotherapy response in locally advanced gastric cancer.Scientific reports · 2025Article
- Prognostic Nutritional Index as an Indicator of Postoperative Morbidity in Patients Undergoing Perioperative Chemotherapy and Surgery for Carcinoma Stomach.Indian journal of surgical oncology · 2025Article
- Development and validation of a nomogram model for predicting infection after radical resection of gastric cancer.Pakistan journal of medical sciences · 2025Article
- Prognostic Nutritional Index as a Predictor of Complications Following Robot-Assisted Radical Cystectomy.Cureus · 2025Article
- Baseline and changes in prognostic nutritional index associate with heart failure hospitalization and all-cause death in patients with cardiac pacemaker.BMC cardiovascular disorders · 2025Observational
- A nutrition-based nomogram for predicting intra-abdominal infection after D2 radical gastrectomy for gastric cancer.Langenbeck's archives of surgery · 2025Article
- Predictive value of preoperative L3-SMI, AGR, and PNI for overall survival in patients undergoing radical gastrectomy for gastric cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Article
- Nutritional trajectories in gastric cancer patients with early oral feeding.Frontiers in nutrition · 2025Article
- Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveTo investigate the influence of pre-operative immunological and nutritional status, assessed by the prognostic nutritional index (PNI) score, on post-operative infection, and the potential additive effects of low PNI and infection on prognosis after radical resection of stage II/III gastric cancer (GC).
methodsThe medical records of 2352 consecutive stage II/III GC patients who underwent radical gastrectomy were retrospectively reviewed. The independent predictors for infections were identified using univariate and multivariate analyses. Cox regression analysis was used to assess any associations between PNI, infection and OS.
resultsA total of 160 (6.8%) cases developed infections and low PNI (< 43.9) was confirmed as an independent predictor. Both PNI < 43.9 and infections independently predicted poor OS (hazard ratio: 1.163, 95% confidence interval: 1.007-1.343; HR: 1.347, 95%CI: 1.067-1.700), and an additive effect was confirmed as patients with both low PNI and infection had worst OS. Further stratified analyses showed that complete peri-operative adjuvant chemotherapy (PAC, ≥ 6 cycles) could significantly improve OS in patients with low PNI and/or infection, which was comparable to those with PNI ≥ 43.9 and/or infection (P = 0.160).
conclusionsInfection was the most common complication after gastrectomy and PNI < 43.9 was identified as an independent predictor. Low PNI was associated with poorer OS in stage II/III GC, independent of infections, and low PNI and infections had a synergistic effect that was associated with worst OS. However, complete PAC could significantly improve OS in these patients. Thus, strategies to decrease infection and complete PAC should be further investigated.
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