Evidence map›Paper›PMID 35354898›Full record

ArticleScientific reports2022

Novel probiotic treatment of autism spectrum disorder associated social behavioral symptoms in two rodent models.

Kitti Mintál, Attila Tóth, Edina Hormay, Anita Kovács, Kristóf László, Anita Bufa, Tamás Marosvölgyi, Béla Kocsis, Adorján Varga, Zoltán Vizvári and 5 more

Abstract read
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In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Intermittent Fasting andNutrients · 2026
    Article
  5. Review
  6. Neuropsychiatric disease and treatment · 2025
    Article
  7. Therapeutic effects ofFrontiers in pharmacology · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
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  15. Article
  16. Review
  17. Review
  18. Review
  19. Diet in treatment of autism spectrum disorders.Frontiers in neuroscience · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kitti MintálInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary. kitti.mintal@aok.pte.hu.
Attila TóthInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Edina HormayInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Anita KovácsInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Kristóf LászlóInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Anita BufaInstitute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary.
Tamás MarosvölgyiInstitute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary.
Béla KocsisDepartment of Medical Microbiology and Immunology, Medical School, University of Pécs, Pécs, Hungary.
Adorján VargaDepartment of Medical Microbiology and Immunology, Medical School, University of Pécs, Pécs, Hungary.
Zoltán VizváriCellular Bioimpedance Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
Renáta CserjésiInstitute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.
László PéczelyInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Tamás OllmannInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
László LénárdInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Zoltán KarádiInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of autism spectrum disorder (ASD) has rapidly increased in the past decades, and several studies report about the escalating use of antibiotics and the consequent disruption of the gastrointestinal microbiome leading to the development of neurobehavioral symptoms resembling to those of ASD. The primary purpose of this study was to investigate whether depletion of the gastrointestinal microbiome via antibiotics treatment could induce ASD-like behavioral symptoms in adulthood. To reliably evaluate that, validated valproic acid (VPA) ASD animal model was introduced. At last, we intended to demonstrate the assessed potential benefits of a probiotic mixture (PM) developed by our research team. Male Wistar rats were used to create antibiotics treated; antibiotics and PM treated; PM treated, VPA treated; VPA and PM treated; and control groups. In all investigations we focused on social behavioral disturbances. Antibiotics-induced microbiome alterations during adulthood triggered severe deficits in social behavior similar to those observed in the VPA model. Furthermore, it is highlighted that our PM proved to attenuate both the antibiotics- and the VPA-generated antisocial behavioral symptoms. The present findings underline potential capacity of our PM to improve social behavioral alterations thus, indicate its promising therapeutic power to attenuate the social-affective disturbances of ASD.

Indexed as

Autism Spectrum DisorderPrenatal Exposure Delayed EffectsProbioticsAnimalsBehavioral SymptomsMaleRatsRats, WistarRodentia

Identifiers

PMID35354898
PMCPMC8967893

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.