ArticleScientific reports2022
Enhancing osseointegration and mitigating bacterial biofilms on medical-grade titanium with chitosan-conjugated liquid-infused coatings.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Chitosan in regenerative medicine: a translational perspective on biomaterial design.Frontiers in bioengineering and biotechnology · 2026Review
- Automated Covalent Microcontact Bioprinting of Lubricant-Infused Microarrays for Biological Assays.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Biologically Active Implants Prevent Mortality in a Mouse Sepsis Model.Advanced healthcare materials · 2025Article
- Biocompatible liquid-infused titanium minimizes oral biofilm adhesion in flow chamber and 3D implant-tissue-biofilmBioactive materials · 2025Article
- Alternating Magnetic Fields Remove Biofilms but Damage Cells on Implant Models Also with Negligible Bulk Heating.ACS applied materials & interfaces · 2025Article
- Micro- and Nano-Bots for Infection Control.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review.Frontiers in bioengineering and biotechnology · 2025Review
- Biomaterials for bone infections: antibacterial mechanisms and immunomodulatory effects.Frontiers in cellular and infection microbiology · 2025Review
- A review on antimicrobial strategies in mitigating biofilm-associated infections on medical implants.Current research in microbial sciences · 2024Review
- Bacterial-Nanocellulose-Based Biointerfaces and Biomimetic Constructs for Blood-Contacting Medical Applications.ACS materials Au · 2023Review
- Biofunctionalization of Porous Titanium Oxide through Amino Acid Coupling for Biomaterial Design.Materials (Basel, Switzerland) · 2023Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium alloys, in particular, medical-grade Ti-6Al-4 V, are heavily used in orthopaedic applications due to their high moduli, strength, and biocompatibility. Implant infection can result in biofilm formation and failure of prosthesis. The formation of a biofilm on implants protects bacteria from antibiotics and the immune response, resulting in the propagation of the infection and ultimately resulting in device failure. Recently, slippery liquid-infused surfaces (LIS) have been investigated for their stable liquid interface, which provides excellent repellent properties to suppress biofilm formation. One of the current limitations of LIS coatings lies in the indistinctive repellency of bone cells in orthopaedic applications, resulting in poor tissue integration and bone ingrowth with the implant. Here, we report a chitosan impregnated LIS coating that facilitates cell adhesion while preventing biofilm formation. The fabricated coating displayed high contact angles (108.2 ± 5.2°) and low sliding angles (3.56 ± 4.3°). Elemental analysis obtained using X-ray photoelectron spectroscopy (XPS) confirmed the availability of fluorine and nitrogen, indicating the presence of fluorosilane and chitosan in the final coating. Furthermore, our results suggest that chitosan-conjugated LIS increased cell adhesion of osteoblast-like SaOS-2 cells and significantly promoted proliferation (a fourfold increase at 7-day incubation) compared to conventional titanium liquid-infused surfaces. Furthermore, the chitosan conjugated LIS significantly reduced biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA) by up to 50% and 75% when compared to untreated titanium and chitosan-coated titanium, respectively. The engineered coating can be easily modified with other biopolymers or capture molecules to be applied to other biomaterials where tissue integration and biofilm prevention are needed.
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