Evidence map›Paper›PMID 35354833›Full record

ArticleScientific reports2022

Genetic alteration of heparan sulfate in CD11c + immune cells inhibits inflammation and facilitates pathogen clearance during influenza A virus infection.

So Young Kim, Purva Gupta, Scott C Johns, Elina I Zuniga, John R Teijaro, Mark M Fuster

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

So Young Kim *Division of Pulmonary and Critical Care, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Purva Gupta *Division of Pulmonary and Critical Care, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Scott C JohnsVA San Diego Healthcare System, Medical and Research Sections, La Jolla, CA, USA.
Elina I ZunigaDivision of Biological Sciences, University of California San Diego, La Jolla, CA, USA.
John R TeijaroThe Scripps Research Institute, La Jolla, CA, USA.
Mark M FusterDivision of Pulmonary and Critical Care, Department of Medicine, University of California San Diego, La Jolla, CA, USA. mfuster@health.ucsd.edu.
VA San Diego Healthcare System · USUniversity of California, San Diego · USScripps Research Institute · US

Funding

Inhibitory Pathways Underlying Viral Persistence In VivoR01AI081923 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elina I Zuniga · 2009 to 2026
$6.6M
UCSD Biomedical Scientist Career Development Program in GlycoscienceK12HL141956 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESKO, JEFFREY D, GODULA, KAMIL · 2018 to 2022
$5.3M
Glycocalyx Targeting and Augmenting Cellular Immunity in Lung CancerI01BX003688 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI FUSTER, MARK M · 2018 to 2025
–
BLRD VA I01 BX003688NHLBI NIH HHS K12 5K12HL141956NHLBI NIH HHS K12 HL141956NIAID NIH HHS R01 AI081923NIAID NIH HHS R01-AI081923VA I01BX003688-01A1
6 · The paper itself

Abstract

Survival from influenza A virus (IAV) infection largely depends on an intricate balance between pathogen clearance and immunomodulation in the lung. We demonstrate that genetic alteration of the glycan heparan sulfate (HS) in CD11c + cells via Ndst1f/f CD11cCre + mutation, which inhibits HS sulfation in a major antigen presenting cell population, reduces lung inflammation by A/Puerto Rico/8/1934(H1N1) influenza in mice. Mutation was also characterized by a reduction in lung infiltration by CD4

Indexed as

Influenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza, HumanAnimalsHeparan SulfateHumansInflammationMiceMutationHeparan Sulfate

Identifiers

PMID35354833
PMCPMC8968721
OpenAlexW4220982645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.