ArticleNature communications2022
Donut-like organization of inhibition underlies categorical neural responses in the midbrain.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Evolutionarily old brainstem neurons are required for the control of selective spatial attention.Nature communications · 2026Article
- Saccades orchestrate intraocular glucose dynamics to shape visual responses in birds.Nature communications · 2026Article
- The dynamics of stimulus selection in the nucleus isthmi pars magnocellularis of avian midbrain network.Scientific reports · 2025Article
- The barn owl in systems and behavioral neuroscience: Progress and promise.Current opinion in neurobiology · 2025Review
- Distinct neural mechanisms construct classical versus extraclassical inhibitory surrounds in an inhibitory nucleus in the midbrain attention network.Nature communications · 2023Article
- Flexible control of representational dynamics in a disinhibition-based model of decision-making.eLife · 2023Article
- Choice selective inhibition drives stability and competition in decision circuits.Nature communications · 2023Article
- Directional Preference in Avian Midbrain Saliency Computing Nucleus Reflects a Well-Designed Receptive Field Structure.Animals : an open access journal from MDPI · 2022Article
- Donut-like organization of inhibition underlies categorical neural responses in the midbrain.Nature communications · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Categorical neural responses underlie various forms of selection and decision-making. Such binary-like responses promote robust signaling of the winner in the presence of input ambiguity and neural noise. Here, we show that a 'donut-like' inhibitory mechanism in which each competing option suppresses all options except itself, is highly effective at generating categorical neural responses. It surpasses motifs of feedback inhibition, recurrent excitation, and divisive normalization invoked frequently in decision-making models. We demonstrate experimentally not only that this mechanism operates in the midbrain spatial selection network in barn owls, but also that it is necessary for categorical signaling by it. The functional pattern of neural inhibition in the midbrain forms an exquisitely structured 'multi-holed' donut consistent with this network's combinatorial inhibitory function for stimulus selection. Additionally, modeling reveals a generalizable neural implementation of the donut-like motif for categorical selection. Self-sparing inhibition may, therefore, be a powerful circuit module central to categorization.
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