ArticleThe American journal of case reports2022
Burst Suppression Electroencephalography (EEG) Pattern with Coma and Loss of Brain Stem Reflexes Following a Baclofen Overdose with Subsequent Full Recovery.
Article in The American journal of case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- An unusual case of burst suppression electrographic pattern following intrathecal baclofen overdose in critical care: a case report.European journal of anaesthesiology and intensive care · 2026Article
- Acute Intoxication After Baclofen Administration: A Review of the Literature and Methodological Proposals.Toxics · 2025Review
- Severe Bradyarrhythmia and Reduced Cardiac Output Due to Oral Baclofen Withdrawal in a 24-Year Old Man: A Case Report.The American journal of case reports · 2025Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND When taken in overdose, baclofen can produce a unique pattern of clinical findings and EEG abnormalities that contrasts to that seen with other sedative hypnotic medications. This includes profound lethargy and coma, loss of basic brainstem reflexes and pupil reactivity, myoclonic jerks and seizures, and a burst suppression pattern on EEG. In the absence of a clear history of ingestion, clinicians may presume the presence of anoxic brain injury and that a progression towards brain death may be imminent. CASE REPORT We report a case of a middle-aged woman found unresponsive who presented with apnea, loss of rudimentary neurologic findings on physical exam, burst suppression EEG findings, and a prolonged comatose state for nearly 48 h, followed by rapid resolution of symptoms secondary to a supratherapeutic baclofen ingestion. CONCLUSIONS Baclofen toxicity can present both clinically and with EEG abnormalities consistent with anoxic brain injury, suggesting an inevitable progression to brain death. When provided with appropriate supportive care and prolonged observation, improvement with full neurologic recovery is often seen despite the initial grim clinical picture.
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