Evidence map›Paper›PMID 35354761›Full record

ArticleJournal of microbiology and biotechnology2022

Immunostimulatory Effect of Heat-Killed Probiotics on RAW264.7 Macrophages.

Hye-Ji Noh, Jung Min Park, Yoo Jin Kwon, Kyunghwan Kim, Sung Yurb Park, Insu Kim, Jong Hyun Lim, Byoung Kook Kim, Byung-Yong Kim

Abstract read
In one paragraph

Article in Journal of microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Effects of Heat-KilledNutrients · 2026
    Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Heat-KilledInternational journal of molecular sciences · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Immunomodulatory activity of heat-killedFood science & nutrition · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hye-Ji NohProbiotics Research Laboratory, Chong Kun Dang Bio Research Institute (CKDBIO), Gyeonggi 15064, Republic of Korea.
Jung Min ParkR&D Center, Chong Kun Dang Healthcare (CKDHC), Seoul 07249, Republic of Korea.
Yoo Jin KwonProbiotics Research Laboratory, Chong Kun Dang Bio Research Institute (CKDBIO), Gyeonggi 15064, Republic of Korea.
Kyunghwan KimProbiotics Research Laboratory, Chong Kun Dang Bio Research Institute (CKDBIO), Gyeonggi 15064, Republic of Korea.
Sung Yurb ParkProbiotics Research Laboratory, Chong Kun Dang Bio Research Institute (CKDBIO), Gyeonggi 15064, Republic of Korea.
Insu KimR&D Center, Chong Kun Dang Healthcare (CKDHC), Seoul 07249, Republic of Korea.
Jong Hyun LimR&D Center, Chong Kun Dang Healthcare (CKDHC), Seoul 07249, Republic of Korea.
Byoung Kook KimProbiotics Research Laboratory, Chong Kun Dang Bio Research Institute (CKDBIO), Gyeonggi 15064, Republic of Korea.
Byung-Yong KimR&D Center, Chong Kun Dang Healthcare (CKDHC), Seoul 07249, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics modulate the gut microbiota, which in turn regulate immune responses to maintain balanced immune homeostasis in the host. However, it is unclear how probiotic bacteria regulate immune responses. In this study we investigated the immunomodulatory effects of heat-killed probiotics, including

Indexed as

Hot TemperatureProbioticsAnimalsCytokinesMacrophagesMiceNitric OxideRAW 264.7 CellsCytokinesNitric Oxideheat-killed probioticsImmunostimulatory effectmacrophages

Identifiers

PMID35354761
PMCPMC9628881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.