Evidence map›Paper›PMID 35354581›Full record

Observational studyNeurology2022

Association of Diabetes and Hypertension With Brain Structural Integrity and Cognition in the Boston Puerto Rican Health Study Cohort.

Yi Guan, Seyed Amir Ebrahimzadeh, Chia-Hsin Cheng, Weifan Chen, Tiffany Leung, Sherman Bigornia, Natalia Palacios, Mahdi O Garelnabi, Tammy Scott, Rafeeque Bhadelia and 3 more

Erratum issued Registry-linked trialOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01231958 (The Boston Puerto Rican Health Study), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01231958 completednot on this map

The Boston Puerto Rican Health Study: Center for Population Health and Health Disparities

TypeobservationalSponsorUniversity of Massachusetts, LowellRan2004 to 2017Enrolled1,650ConditionsCardiovascular Risk FactorArmsThe Heart Healthy Initiative for Hispanic Adults (HIP)
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Metabolites and MRI-derived markers of dementia risk in a Puerto Rican cohort.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
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  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Yi GuanFrom the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.
Seyed Amir EbrahimzadehFrom the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.ORCID 0000-0003-4927-8444
Chia-Hsin ChengFrom the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.
Weifan ChenFrom the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.
Tiffany LeungFrom the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.
Sherman BigorniaFrom the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.
Natalia PalaciosFrom the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.
Mahdi O GarelnabiFrom the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.ORCID 0000-0003-4967-3209
Tammy ScottFrom the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.
Rafeeque BhadeliaFrom the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.
Katherine L TuckerFrom the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.
Bang-Bon KooFrom the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.
Alzheimer's Disease Neuroimaging Initiative
Beth Israel Deaconess Medical Center · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI FAGAN, ANNE · 1985 to 2019
$52.1M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1985 to 2019
$43.0M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0M
VESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GROSSMAN, HILLEL · 1985 to 2019
$37.9M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6M
NHLBI NIH HHS P50 HL105185NIA NIH HHS P01 AG023394NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG072947NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG033514NIA NIH HHS P50 AG047266NIA NIH HHS P50 AG047270NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG055948NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe Boston Puerto Rican Health Study (BPRHS) is a longitudinal study following self-identified Puerto Rican older adults living in the Greater Boston area. Studies have shown higher prevalence of hypertension (HTN) and type 2 diabetes (T2D) within this ethnic group compared to age-matched non-Hispanic White adults. In this study, we investigated the associations of HTN and T2D comorbidity on brain structural integrity and cognitive capacity in community-dwelling Puerto Rican adults and compared these measures with older adult participants (non-Hispanic White and Hispanic) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and National Alzheimer's Coordinating Center (NACC) databases.

methodsBPRHS participants who underwent brain MRI and cognitive testing were divided into 4 groups based on their HTN and T2D status: HTN-/T2D-, HTN+/T2D-, HTN-/T2D+, and HTN+/T2D+. We assessed microstructural integrity of white matter (WM) pathways using diffusion MRI, brain macrostructural integrity using hippocampal volumes, and brain age using T1-weighted MRI and cognitive test scores. BPRHS results were then compared with results from non-Hispanic White and Hispanic participants from the ADNI and NACC databases.

resultsThe prevalence of HTN was almost 2 times (66.7% vs 38.7%) and of T2D was 5 times (31.8% vs 6.6.%) higher in BPRHS than in ADNI non-Hispanic White participants. Diffusion MRI showed clear deterioration patterns in major WM tracts in the HTN+/T2D+ group and, to a lesser extent, in the HTN+/T2D- group compared to the HTN-/T2D- group. HTN+/T2D+ participants also had the smallest hippocampal volume and larger brain aging deviations. Trends toward lower executive function and global cognitive scores were observed in HTN+/T2D+ relative to HTN-/T2D- individuals. MRI measures and the Mini-Mental State Examination (MMSE) scores from the HTN+/T2D+ BPRHS group resembled those of ADNI White participants with progressive mild cognitive impairment (MCI), while the BPRHS HTN-/T2D- participants resembled participants with stable MCI. The BPRHS was not significantly different from the ADNI + NACC Hispanic cohort on imaging or MMSE measures. DISCUSSION: The effects of T2D and HTN comorbidity led to greater brain structural disruptions than HTN alone. The high prevalence of HTN and T2D in the Puerto Rican population may be a key factor contributing to health disparities in cognitive impairment in this group compared to non-Hispanic White adults in the same age range. TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov identifier: NCT01231958.

Indexed as

Diabetes Mellitus, Type 2HypertensionWhite MatterAgedAlzheimer DiseaseCognitionHispanic or LatinoHumansLongitudinal Studies

Identifiers

PMID35354581
PMCPMC9012269
OpenAlexW4220746852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.