Evidence map›Paper›PMID 35354384›Full record

ArticleBMC medical imaging2022

Heart and bladder detection and segmentation on FDG PET/CT by deep learning.

Xiaoyong Wang, Skander Jemaa, Jill Fredrickson, Alexandre Fernandez Coimbra, Tina Nielsen, Alex De Crespigny, Thomas Bengtsson, Richard A D Carano

Open access · goldAbstract read
In one paragraph

Article in BMC medical imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Physical and engineering sciences in medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaoyong WangGenentech, Inc., South San Francisco, CA, USA. wang.xiaoyong@gene.com.
Skander JemaaGenentech, Inc., South San Francisco, CA, USA.
Jill FredricksonGenentech, Inc., South San Francisco, CA, USA.
Alexandre Fernandez CoimbraGenentech, Inc., South San Francisco, CA, USA.
Tina NielsenF. Hoffman-La Roche Ltd., Basel, Switzerland.
Alex De CrespignyGenentech, Inc., South San Francisco, CA, USA.
Thomas BengtssonGenentech, Inc., South San Francisco, CA, USA.
Richard A D CaranoGenentech, Inc., South San Francisco, CA, USA.
Roche (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePositron emission tomography (PET)/ computed tomography (CT) has been extensively used to quantify metabolically active tumors in various oncology indications. However, FDG-PET/CT often encounters false positives in tumor detection due to APPROACH: A deep learning based approach is proposed to segment the heart and bladder on whole body PET/CT automatically. Two 3D U-Nets were developed separately to segment the heart and bladder, where each network receives the PET and CT as a multi-modal input. Data sets were obtained from retrospective clinical trials and include 575 PET/CT for heart segmentation and 538 for bladder segmentation.

resultsThe models were evaluated on a test set from an independent trial and achieved a Dice Similarity Coefficient (DSC) of 0.96 for heart segmentation and 0.95 for bladder segmentation, Average Surface Distance (ASD) of 0.44 mm on heart and 0.90 mm on bladder.

conclusionsThis methodology could be a valuable component to the FDG-PET/CT data processing chain by removing FDG physiological noise associated with heart and/or bladder accumulation prior to image analysis by manual, semi- or automated tumor analysis methods.

Indexed as

Deep LearningFluorodeoxyglucose F18HumansPositron Emission Tomography Computed TomographyRetrospective StudiesUrinary BladderFluorodeoxyglucose F18Deep learningFDG PET/CTPhysiological noiseSegmentation

Identifiers

PMID35354384
PMCPMC8977865
OpenAlexW4220734310

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.