Evidence map›Paper›PMID 35354308›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2022

Macrophage ALDH2 (Aldehyde Dehydrogenase 2) Stabilizing Rac2 Is Required for Efferocytosis Internalization and Reduction of Atherosclerosis Development.

Jian Zhang, Xiangkai Zhao, Yunyun Guo, Zhiping Liu, Shujian Wei, Qiuhuan Yuan, Haixia Shang, Wentao Sang, Sumei Cui, Tonghui Xu and 8 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Journal of the American Heart Association · 2026
    Article
  4. Article
  5. AldehydeFrontiers in medicine · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Biomechanics-mediated endocytosis in atherosclerosis.Frontiers in cardiovascular medicine · 2024
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Jian Zhang *Department of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Xiangkai Zhao *Department of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Yunyun GuoDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Zhiping LiuCenter of Intelligent Medical Engineering, School of Control Science and Engineering, Shandong University, Jinan, China (Z.L., H.S.).
Shujian WeiDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Qiuhuan YuanDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Haixia ShangCenter of Intelligent Medical Engineering, School of Control Science and Engineering, Shandong University, Jinan, China (Z.L., H.S.).
Wentao SangDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Sumei CuiDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Tonghui XuDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.ORCID 0000-0002-4670-3727
Kehui YangDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Jialin GuoDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Chang PanDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Jiali WangDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Jiaojiao PangDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Tianrui HanDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Yuguo ChenDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Feng XuDepartment of Emergency Medicine (J.Z., X.Z., Y.G., S.W., Q.Y., W.S., S.C., T.X., K.Y., J.G., C.P., J.W., J.P., T.H., Y.C., F.X.), Qilu Hospital, Shandong University, Jinan, China.
Qilu University of Technology · CNUniversity of Jinan · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinical studies show that the most common single-point mutation in humans, ALDH2 (aldehyde dehydrogenase 2) rs671 mutation, is a risk factor for the development and poor prognosis of atherosclerotic cardiovascular diseases, but the underlying mechanism remains unclear. Apoptotic cells are phagocytosed and eliminated by macrophage efferocytosis during atherosclerosis, and enhancement of arterial macrophage efferocytosis reduces atherosclerosis development.

methodsPlaque areas, necrotic core size, apoptosis, and efferocytosis in aortic lesions were investigated in APOE

resultsWe found that transplanting bone marrow from APOE

conclusionsOur study has uncovered a pivotal role of the ALDH2-Rac2 axis in mediating efferocytosis during atherosclerosis, highlighting a potential therapeutic strategy in cardiovascular diseases, especially for ALDH2 rs671 mutation carriers.

Indexed as

AtherosclerosisCardiovascular DiseasesPlaque, AtheroscleroticAldehyde Dehydrogenase, MitochondrialAnimalsApolipoproteins EApoptosisMacrophagesMiceMice, Inbred C57BLMice, KnockoutRAC2 GTP-Binding Proteinrac GTP-Binding ProteinsAldehyde Dehydrogenase, MitochondrialALDH2 protein, mouseApolipoproteins ERAC2 GTP-Binding Proteinrac GTP-Binding Proteinsapoptosisatherosclerosismacrophageproteomics

Identifiers

PMID35354308
PMCPMC9126264
OpenAlexW4221091509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.