ArticleCell reports2022
Developmental coupling of cerebral blood flow and fMRI fluctuations in youth.
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41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Common neural dysfunction in psychiatric disorders: Insights from a meta-analysis of resting-state fMRI studies.Translational psychiatry · 2025Pooled it
- Abnormalities of cerebral blood flow and the regional brain function in Parkinson's disease: a systematic review and multimodal neuroimaging meta-analysis.Frontiers in neurology · 2023Pooled it
- Prefrontal Neurovascular Coupling Abnormalities Associated With Cognitive Performance in Multiple Sclerosis.CNS neuroscience & therapeutics · 2026Article
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- Leveraging Task FMRI Data to Extract Resting-State Metrics in Brain Tumor and Healthy Populations.Clinical neuroradiology · 2026Article
- Exploration of brain function changes in the visual cortex of astigmatic subjects based on fNIRS.Scientific reports · 2026Article
- Testing for Network Specificity in Brain-Behavior Associations Using Ordinal Dominance Curves.Human brain mapping · 2026Article
- Paediatric traumatic brain injury: unique population and unique challenges.Brain : a journal of neurology · 2026Review
- Neurovascular Coupling Disruption and Glymphatic Dysfunction Are Associated With Visual Impairment in Pediatric Monocular Anisometropic Amblyopia.Investigative ophthalmology & visual science · 2026Article
- In vivo mapping of cortical amyloid beta-myelin coupling in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Altered neurovascular coupling and associated neurotransmitter profiles in inflammatory bowel disease with distinct depressive symptoms.Journal of neuroinflammation · 2026Article
- Convergent functional, white-matter microstructural, and cerebral perfusion abnormalities in overweight and obese adults: a multimodal MRI study.Frontiers in nutrition · 2026Article
- Neurovascular coupling abnormalities in first-episode drug-naïve major depressive disorder patients.BMC psychiatry · 2025Article
- Exploring communication impairments in children with spastic cerebral palsy through neurovascular coupling: a cross-sectional study.Quantitative imaging in medicine and surgery · 2025Article
- Neural effect of childhood maltreatment on neurovascular coupling in adolescent depression.European child & adolescent psychiatry · 2025Article
- Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness.Communications biology · 2025Article
- Mapping Individual Differences in Intermodal Coupling in Neurodevelopment.bioRxiv : the preprint server for biology · 2025Article
- Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents.Microbiome · 2025Article
- Western diet since adolescence impairs brain functional hyperemia at adulthood in mice: rescue by a balanced ω-3:ω-6 polyunsaturated fatty acids ratio.International journal of obesity (2005) · 2025Article
- Temporal Lobe Epilepsy Perturbs the Brain-Wide Excitation-Inhibition Balance: Associations with Microcircuit Organization, Clinical Parameters, and Cognitive Dysfunction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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Authors and funding
21 authors.
Erica B BallerPenn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Richards Building, 5th Floor, Suite 5A, 3700 Hamilton Walk, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alessandra M ValcarcelPenn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Azeez AdebimpePenn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Richards Building, 5th Floor, Suite 5A, 3700 Hamilton Walk, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Aaron Alexander-BlochDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zaixu CuiPenn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Richards Building, 5th Floor, Suite 5A, 3700 Hamilton Walk, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ruben C GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Raquel E GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bart L LarsenPenn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Richards Building, 5th Floor, Suite 5A, 3700 Hamilton Walk, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kristin A LinnPenn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Carly M O'DonnellPenn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Adam R PinesPenn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Richards Building, 5th Floor, Suite 5A, 3700 Hamilton Walk, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Armin RaznahanNational Institute of Mental Health, NIH, IRP, Bethesda, MD 20892, USA.
David R RoalfDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Valerie J SydnorPenn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Richards Building, 5th Floor, Suite 5A, 3700 Hamilton Walk, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tinashe M TaperaPenn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Richards Building, 5th Floor, Suite 5A, 3700 Hamilton Walk, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
M Dylan TisdallDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Simon VandekarDepartment of Biostatistics, Vanderbilt University, Nashville, TN 37203, USA.
Cedric H XiaPenn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Richards Building, 5th Floor, Suite 5A, 3700 Hamilton Walk, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
John A DetreDepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Russell T ShinoharaPenn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA 19104, USA.
Theodore D SatterthwaitePenn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Richards Building, 5th Floor, Suite 5A, 3700 Hamilton Walk, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: sattertt@pennmedicine.upenn.edu.
Funding
Section on Developmental NeurogenomicsZIAMH002949 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI RAZNAHAN, ARMIN · 2016 to 2025
$30.0MNeurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089983 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2009 to 2011
$14.3M2/2 Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089924 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI HAKONARSON, HAKON · 2009 to 2011
$10.7MLongitudinal Mapping of Network Development Underlying Executive Dysfunction in AdolescenceR01MH113550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Danielle Smith Bassett, Theodore Satterthwaite · 2018 to 2026
$6.9MSCHIZOPHRENIA: A NEUROPSYCHIATRIC PERSPECTIVET32MH019112 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 1990 to 2024
$6.2MPersonalized Functional Network Modeling to Characterize and Predict Psychopathology in YouthR01EB022573 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yong Fan, Theodore Satterthwaite · 2016 to 2026
$6.0MInter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9MTRAINING PROGRAM IN NEUROPSYCHOPHARMACOLOGY-PREDOCTORALT32MH014654 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BERRETTINI, WADE H · 1985 to 2021
$5.0MPrecision mapping of individualized executive networks in youthR37MH125829 · NIMH · UNIVERSITY OF MINNESOTA · PI Damien A Fair, Theodore Satterthwaite · 2021 to 2026
$4.7MHarmonization of Multi-Site Neuroimaging Data from Complex Study DesignsR01MH123550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2020 to 2025
$4.0MUltra-high field GluCEST MRI and MRS in youth at risk for psychosisR01MH120174 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2020 to 2024
$3.8MOlfactory and facial markers of developmental risk for psychosis in 22q11 deletion syndromeR01MH119185 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2019 to 2024
$3.5MNIA NIH HHS R56 AG066656NIBIB NIH HHS R01 EB022573NIMH NIH HHS F31 MH123063NIMH NIH HHS R01 MH107235NIMH NIH HHS R01 MH112847NIMH NIH HHS R01 MH113550NIMH NIH HHS R01 MH119185NIMH NIH HHS R01 MH120174NIMH NIH HHS R01 MH120482NIMH NIH HHS R01 MH123550NIMH NIH HHS R37 MH125829NIMH NIH HHS RC2 MH089924NIMH NIH HHS RC2 MH089983NIMH NIH HHS RF1 MH121867NIMH NIH HHS T32 MH014654NIMH NIH HHS T32 MH019112
Abstract
The functions of the human brain are metabolically expensive and reliant on coupling between cerebral blood flow (CBF) and neural activity, yet how this coupling evolves over development remains unexplored. Here, we examine the relationship between CBF, measured by arterial spin labeling, and the amplitude of low-frequency fluctuations (ALFF) from resting-state magnetic resonance imaging across a sample of 831 children (478 females, aged 8-22 years) from the Philadelphia Neurodevelopmental Cohort. We first use locally weighted regressions on the cortical surface to quantify CBF-ALFF coupling. We relate coupling to age, sex, and executive functioning with generalized additive models and assess network enrichment via spin testing. We demonstrate regionally specific changes in coupling over age and show that variations in coupling are related to biological sex and executive function. Our results highlight the importance of CBF-ALFF coupling throughout development; we discuss its potential as a future target for the study of neuropsychiatric diseases.
Indexed as
Cerebrovascular CirculationMagnetic Resonance ImagingAdolescentAdultBrainBrain MappingChildFemaleHumansSpin LabelsYoung AdultSpin Labelsadolescenceamplitude of low-frequency fluctuationscerebral blood flowCP: Neurosciencedevelopmentexecutive functionfrontoparietalneurovascular couplingsex differences
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