ArticleCell reports2022
Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection.
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Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Deciphering Neutral Ceramidase-Dependent Mechanism of Response to Aromatic Fungicides Stress inJournal of fungi (Basel, Switzerland) · 2026Article
- Targeted analysis of sphingolipids and cytokines in plasma of dairy cows after calving reveals distinct impacts of systemic inflammation, ketosis, and mastitis.Journal of animal science and biotechnology · 2026Article
- Intestinal neutral ceramidase, microbial metabolites and epithelial fucosylation in MASH.eGastroenterology · 2026Article
- Intestinal neutral ceramidase exacerbates MASH pathogenesis.eGastroenterology · 2026Article
- Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis.Immunity · 2025Article
- Endothelial cell-ILC3 crosstalk via the ET-1/EDNRA axis promotes NKp46Cellular & molecular immunology · 2025Article
- Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis.Scientific reports · 2025Article
- Targeting hyaluronan synthesis enhances the therapeutic effectiveness of biologics in inflammatory bowel disease.JCI insight · 2025Article
- Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis.Journal of nanobiotechnology · 2024Article
- Ningxiang Pig-Derived Microbiota Affects the Growth Performance, Gut Microbiota, and Serum Metabolome of Nursery Pigs.Animals : an open access journal from MDPI · 2024Article
- Revisiting the Injury Mechanism of Goat Sperm Caused by the Cryopreservation Process from a Perspective of Sperm Metabolite Profiles.International journal of molecular sciences · 2024Article
- The diverse roles of sphingolipids in inflammatory bowel disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Review
- Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages.Nature communications · 2024Article
- Hepatic Transcriptome and Its Regulation Following Soluble Epoxide Hydrolase Inhibition in Alcohol-Associated Liver Disease.The American journal of pathology · 2024Article
- Effects of different Lys/Met ratios on the antioxidant capacity, tissue morphology, and fatty acid composition of subcutaneous fat in Tibetan sheep on low-protein diets: a lipidomic analysis.Frontiers in veterinary science · 2024Article
- Fut2 Deficiency Promotes Intestinal Stem Cell Aging by Damaging Mitochondrial Functions via Down-Regulating α1,2-Fucosylation of Asah2 and Npc1.Research (Washington, D.C.) · 2024Article
- Metabolite itaconate in host immunoregulation and defense.Cellular & molecular biology letters · 2023Review
- Vitamin D alleviates non-alcoholic fatty liver diseaseFrontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 2 countries.
Rui SunDepartment of Surgery, Division of Immunotherapy, University of Louisville, CTRB 311, 505 South Hancock Street, KY 40202, USA; Department of Oncology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430033, China; Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Xuemei GuBrown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Chao LeiDepartment of Surgery, Division of Immunotherapy, University of Louisville, CTRB 311, 505 South Hancock Street, KY 40202, USA; Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Liang ChenDepartment of Surgery, Division of Immunotherapy, University of Louisville, CTRB 311, 505 South Hancock Street, KY 40202, USA; Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Shenghui ChuDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.
Guangzhong XuDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.
Mark A DollDepartment of Pharmacology & Toxicology, University of Louisville, Louisville, KY 40202, USA.
Yi TanDepartment of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
Wenke FengDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA; Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY 40202, USA; Alcohol Research Center, University of Louisville, Louisville, KY 40202, USA; Hepatobiology & Toxicology Center, University of Louisville, Louisville, KY 40202, USA.
Leah SiskindBrown Cancer Center, University of Louisville, Louisville, KY 40202, USA; Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY 40202, USA.
Craig J McClainDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA; Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY 40202, USA; Alcohol Research Center, University of Louisville, Louisville, KY 40202, USA; Hepatobiology & Toxicology Center, University of Louisville, Louisville, KY 40202, USA; Robley Rex VA Medical Center, Louisville, KY, USA.
Zhongbin DengDepartment of Surgery, Division of Immunotherapy, University of Louisville, CTRB 311, 505 South Hancock Street, KY 40202, USA; Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA; Alcohol Research Center, University of Louisville, Louisville, KY 40202, USA; Hepatobiology & Toxicology Center, University of Louisville, Louisville, KY 40202, USA. Electronic address: zhongbin.deng@louisville.edu.
University of Louisville · US
Funding
The role of neutral ceramidase in acute kidney injury and its progression to chronic kidney disease.R01DK124112 · NIDDK · UNIVERSITY OF LOUISVILLE · PI SISKIND, LEAH J · 2020 to 2023
$2.1MCSN8 regulation of S1P-enriched extracellular vesicles to modulate NAFLD by gut-liver axisR01DK115406 · NIDDK · UNIVERSITY OF LOUISVILLE · PI DENG, ZHONG-BIN · 2018 to 2022
$2.0MGut extracellular vesicles promote alcohol-induced liver injury via TLR4-regulated miRNAsR21AA025724 · NIAAA · UNIVERSITY OF LOUISVILLE · PI DENG, ZHONG-BIN · 2018 to 2019
$558kDefining the role of S1p and myeloid cells during enterotoxigenic B. fragilis infectionR21AI159194 · NIAID · UNIVERSITY OF LOUISVILLE · PI DENG, ZHONG-BIN · 2021 to 2022
$430kIntestinal epithelial cells-derived exosomal miRNAs regulate liver inflammation in obesityR21AI128206 · NIAID · UNIVERSITY OF LOUISVILLE · PI DENG, ZHONG-BIN · 2017 to 2018
$424kNIAAA NIH HHS R21 AA025724NIAID NIH HHS R21 AI128206NIAID NIH HHS R21 AI159194NIDDK NIH HHS R01 DK115406NIDDK NIH HHS R01 DK124112
Abstract
It is not clear how the complex interactions between diet and intestinal immune cells protect the gut from infection. Neutral ceramidase (NcDase) plays a critical role in digesting dietary sphingolipids. We find that NcDase is an essential factor that controls intestinal immune cell dynamics. Mice lacking NcDase have reduced cluster of differentiation (CD) 8αβ
Indexed as
Neutral CeramidaseSphingosineAnimalsHomeostasisIntestine, SmallMacrophagesMiceNeutral CeramidaseSphingosineceramideCP: ImmunologyCP: Microbiologydefenseextracellular vesiclesglycolysisinflammasomesinnateintestinemucosal immunologysphingolipidTh1 cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.