ArticleCell reports2022
Dopamine neurons evaluate natural fluctuations in performance quality.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Striatal Dopamine at Learned Sequence Boundaries Sustains Birdsong.bioRxiv : the preprint server for biology · 2026Article
- Prediction error correlates in the striosome-dopamine circuit emerge from information gain.Nature communications · 2026Article
- Dopaminergic Innervation of the Nidopallium Caudolaterale in the Japanese Quail.The Journal of comparative neurology · 2026Article
- Sharp Waves, Bursts, and Coherence: Activity in a Songbird Vocal Circuit Is Influenced by Behavioral State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated review.PeerJ · 2025Review
- Neural sensitivity to frequency changes in song structure in a high-order auditory area reflects tutor song memory in adult songbirds.Brain structure & function · 2024Article
- Striatal Dopamine Contributions to Skilled Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Learning the sound inventory of a complex vocal skill via an intrinsic reward.Science advances · 2024Article
- Striatal dopamine contributions to skilled motor learning.bioRxiv : the preprint server for biology · 2024Article
- Tutor auditory memory for guiding sensorimotor learning in birdsong.Frontiers in neural circuits · 2024Review
- Dopamine Increases Accuracy and Lengthens Deliberation Time in Explicit Motor Skill Learning.eNeuro · 2024Article
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- Task parameters influence operant response variability in mice.Psychopharmacology · 2023Article
- Songbird mesostriatal dopamine pathways are spatially segregated before the onset of vocal learning.PloS one · 2023Article
- Birdsong.Current biology : CB · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
Many motor skills are learned by comparing ongoing behavior to internal performance benchmarks. Dopamine neurons encode performance error in behavioral paradigms where error is externally induced, but it remains unknown whether dopamine also signals the quality of natural performance fluctuations. Here, we record dopamine neurons in singing birds and examine how spontaneous dopamine spiking activity correlates with natural fluctuations in ongoing song. Antidromically identified basal ganglia-projecting dopamine neurons correlate with recent, and not future, song variations, consistent with a role in evaluation, not production. Furthermore, maximal dopamine spiking occurs at a single vocal target, consistent with either actively maintaining the existing song or shifting the song to a nearby form. These data show that spontaneous dopamine spiking can evaluate natural behavioral fluctuations unperturbed by experimental events such as cues or rewards.
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