ArticleScience translational medicine2022
Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates.
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Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Bronchopulmonary dysplasia and prematurity-associated lung disease: emerging therapies to improve lifelong respiratory outcomes.European journal of pediatrics · 2026Review
- Mesenchyme-derived inflammation during the saccular stage recruits macrophages and alters lung development.JCI insight · 2026Article
- A single-cell transcriptomic atlas of the pigtail macaque placenta in late gestation.BMC genomics · 2026Article
- Vascular Endothelial Growth Factor-D Improves Lung Vascular Integrity During Acute Lung Injury.Circulation research · 2026Article
- Engraftment of wild-type alveolar type II epithelial cells in surfactant protein C deficient mice.NPJ Regenerative medicine · 2026Article
- The evolving pathophysiology of bronchopulmonary dysplasia.Physiological reviews · 2026Review
- Mitochondrial quality control mechanisms as molecular targets for impaired lung development: from fetuses to neonates.Respiratory research · 2025Review
- The Impact of Maternal Gut Dysbiosis on Embryo/Fetus Development.Cell proliferation · 2025Article
- Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung.bioRxiv : the preprint server for biology · 2025Article
- Pulmonary and neurobehavioral efficacies of AVR-48, a TLR4 modulator, in a preterm lamb model of bronchopulmonary dysplasia.Respiratory research · 2025Article
- Single-cell analysis of the decidua unveils the mechanism of anti-inflammatory exosomes for chorioamnionitis in nonhuman primates.Science advances · 2025Article
- Perinatal Antibiotic Exposure and Respiratory Outcomes in Children Born Preterm.JAMA network open · 2025Article
- Ascending Vaginal Infection in Mice Induces Preterm Birth and Neonatal Morbidity.The American journal of pathology · 2025Article
- Specialized Pulmonary Vascular Cells in Development and Disease.Annual review of physiology · 2025Review
- Histological Chorioamnionitis Increases the Risk of Bronchopulmonary Dysplasia.American journal of respiratory and critical care medicine · 2024Article
- Standardized Digital Method for Histological Evaluation of Experimental Acute Lung Injury.American journal of respiratory cell and molecular biology · 2023Article
- Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia.American journal of respiratory and critical care medicine · 2023Article
- An endogenous amniotic fluid-derived 10-amino acid peptide improves lung development and hyperoxia injury.Translational pediatrics · 2023Article
- Elevated expression of Toll-like receptor 4 and cytokines in both serum and myometrium at term may serve as promising biomarkers for uterine activation preceding labor.Frontiers in endocrinology · 2023Article
- Alleviation of Severe Skin Insults Following High-Dose Irradiation with Isolated Human Fetal Placental Stromal Cells.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
33 authors at 5 institutions in 1 country.
Andrea TothPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-8924-8499
Shelby SteinmeyerPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Paranthaman KannanPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jerilyn GrayPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-3735-1360
Courtney M JacksonDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-1777-688X
Shibabrata MukherjeeDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Martin DemmertDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-7552-3736
Joshua R SheakPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-8002-4365
Daniel BensonPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-5452-3091
Joseph KitzmillerPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0003-1670-526X
Joseph A WaymanDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Pietro PresicceDivisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-2690-1814
Christopher CatesDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Rhea RubinDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Kashish ChetalDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Yina DuPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Yifei MiaoPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Mingxia GuPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-7405-8473
Minzhe GuoPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-5502-9172
Vladimir V KalinichenkoPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0003-3438-2660
Suhas G KallapurDivisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
Emily R MiraldiDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-0232-3116
Yan XuPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0003-2025-027X
Daniel SwarrPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-7305-0442
Ian LewkowichDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-8133-3568
Nathan SalomonisDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-9689-2469
Lisa MillerCalifornia National Primate Research Center, University of California Davis, Davis, CA, USA.ORCID 0000-0001-7557-1316
Jennifer S SucreDivision of Neonatology, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID 0000-0002-6613-1439
Jeffrey A WhitsettPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Claire A ChougnetDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0003-0217-3442
Alan H JobePerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0003-3632-4114
Hitesh DeshmukhPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-9632-164X
William J ZachariasPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-2643-0610
Cincinnati Children's Hospital Medical Center · USUniversity of California, Los Angeles · USUniversity of Cincinnati Medical Center · USUniversity of California, Davis · USVanderbilt University · US
Funding
National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5MThe LungMAP Data Coordination Center for Next Gen Systems Biology of RespirationU24HL148865 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Bruce J Aronow, Nathan G. Salomonis · 2019 to 2026
$12.4MEditing Alveolar Progenitor Cells for Correction of Monogenic DiseaseU01HL134745 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KOTTON, DARRELL N., MORRISEY, EDWARD E · 2016 to 2022
$8.3MDynamic regulatory network models of human response to influenza virusU01AI150748 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARAZZI, IVAN, MIRALDI, EMILY · 2020 to 2024
$5.8MFox Transcription Factors in Development of Pulmonary CapillariesR01HL084151 · NHLBI · UNIVERSITY OF CHICAGO · PI KALINICHENKO, VLADIMIR · 2006 to 2018
$4.9MTranscriptional Regulation of Endothelial Cells after Neonatal Lung InjuryR01HL141174 · NHLBI · UNIVERSITY OF ARIZONA · PI Vladimir Kalinichenko · 2018 to 2026
$4.7M"Lung MAP" Atlas Research CenterU01HL122642 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI POTTER, S. STEVEN, WHITSETT, JEFFREY A · 2014 to 2018
$3.9MTranscriptomics and biomarkers of fetal neuroinflammationR01HD098389 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KALLAPUR, SUHAS · 2019 to 2023
$3.8MDevelopment of novel therapeutic approaches for treatment of Alveolar Capillary DysplasiaR01HL152973 · NHLBI · UNIVERSITY OF ARIZONA · PI Vladimir Kalinichenko · 2021 to 2026
$3.6MAn experimentally-refined, dynamic gene regulatory network model of T-cell memoryR01AI153442 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI BARSKI, ARTEM, MIRALDI, EMILY · 2021 to 2025
$3.2MUterine signaling networks in the pathogenesis of pulmonary lymphangioleiomyomatosis (LAM)R01HL153045 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI XU, YAN, YU, JANE · 2020 to 2023
$3.1MRole of Microbiome in Neonatal Lung Maturation and Immune SusceptibilityR01AI138553 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MILLER, LISA A · 2018 to 2023
$2.9MNHLBI NIH HHS K08 HL140178NHLBI NIH HHS K08 HL143051NHLBI NIH HHS K99 HL135258NHLBI NIH HHS L40 HL138848NHLBI NIH HHS R00 HL135258NHLBI NIH HHS R01 HL084151NHLBI NIH HHS R01 HL123490NHLBI NIH HHS R01 HL141174NHLBI NIH HHS R01 HL142708NHLBI NIH HHS R01 HL149366NHLBI NIH HHS R01 HL149631NHLBI NIH HHS R01 HL152973NHLBI NIH HHS R01 HL153045NHLBI NIH HHS R01 HL155611NHLBI NIH HHS R01 HL156860NHLBI NIH HHS R01 HL164414NHLBI NIH HHS R21 HL142485NHLBI NIH HHS U01 HL122642NHLBI NIH HHS U01 HL134745NHLBI NIH HHS U24 HL148865NIAID NIH HHS R01 AI138553NIAID NIH HHS R01 AI153442NIAID NIH HHS U01 AI150748NICHD NIH HHS K08 HD084686NICHD NIH HHS R01 HD098389NIEHS NIH HHS U01 ES029234NIH HHS P51 OD011107
Abstract
Perinatal inflammatory stress is associated with early life morbidity and lifelong consequences for pulmonary health. Chorioamnionitis, an inflammatory condition affecting the placenta and fluid surrounding the developing fetus, affects 25 to 40% of preterm births. Severe chorioamnionitis with preterm birth is associated with significantly increased risk of pulmonary disease and secondary infections in childhood, suggesting that fetal inflammation may markedly alter the development of the lung. Here, we used intra-amniotic lipopolysaccharide (LPS) challenge to induce experimental chorioamnionitis in a prenatal rhesus macaque (
Indexed as
ChorioamnionitisPremature BirthAnimalsFemaleLungMacaca mulattaPregnancyPulmonary Gas Exchange
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